General
Preferred name
CREATINE
Synonyms
Methylguanidoacetic acid ()
Creatine ALS-08 ()
Creatine monohydrate ()
Methylguanidoacetic acid monohydrate ()
Kreatinum ()
NSC-8752 ()
Neotine ()
Cosmocair c 100 ()
Creatine (hydrate) ()
P&D ID
PD010201
CAS
6020-87-7
57-00-1
1093737-19-9
Tags
natural product
drug
available
Approved by
FDA
Drug Status
nutraceutical
investigational
approved
Drug indication
Motor neurone disease
Max Phase
Phase 3
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS
Creatine is a essential, non-proteinaceous amino acid found in all animals. It is synthesized in the kidney, liver, and pancreas from L-arginine, glycine and L-methionine. Following its biosynthesis, creatine is transported to the skeletal muscle, heart, brain and other tissues. Most of the creatine is metabolized in these tissues to phosphocreatine (creatine phosphate). Phosphocreatine is a major energy storage form in the body. Supplemental creatine may have an energy-generating action during anaerobic exercise and may also have neuroprotective and cardioprotective actions.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
19
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
52
Molecular Weight
131.07
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.1
TPSA
90.41
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
0.0
QED
0.33
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Metabolic Enzyme/Protease
Target
Endogenous Metabolite
CKB, CKM, CKMT1A, CKMT2, GAMT, SLC6A8
IFN,JAK
Member status
member
MOA
ADP to ATP Phosphate donor
Creatine Kinase substrate
Source data
