General
Preferred name
THIAMINE
Synonyms
THIAMINE HYDROCHLORIDE ()
Thiamine (vit b1) ()
Thiaminum ()
THIAMINE CHLORIDE ()
Vitamin B1 ()
Vitamin B1 hydrochloride ()
Thiamine HCl ()
Thiamine chloride hydrochloride ()
Vitamin B1 nitrate ()
THIAMINE ION ()
THIAMINE HYDROCHLORIDE (Vitamin B1) ()
[3H]thiamine ()
Thiamine HCl (Vitamin B1) ()
Thiamine monochloride ()
Thiamine nitrate ()
Thiamine (hydrochloride) ()
Thiamine chloride (hydrochloride) ()
Vitamin B1 (hydrochloride) ()
THIAMINE MONONITRATE ()
Thiamine (nitrate) ()
FEMA NO. 3322 ()
Thiamine chloride, hydrochloride ()
Thiaminum hydrochloricum ()
Vit B1 ()
Clotiamina ()
Betalin S ()
Benerva ()
Bevitine ()
Vit B1 Thiamin ()
Eskaphen ()
NSC-36226 ()
Bevitol ()
Tyvera ()
Thiamini hydrochloridum ()
Thymine hydrochloride ()
Betamin ()
Thiacoat ()
Bethiamin ()
Thiamin ()
Vitaneurin ()
Aneurine ()
Beivon ()
Thiamine component of vitaped ()
Apatate drape ()
Vitamin b-1 ()
Oryzanin ()
Tiamina ()
Thiamin mononitrate ()
Aneurine mononitrate ()
Thiamine nitrate (salt) ()
Vitamin b1 (as thiamine nitrate) ()
Betabion mononitrate ()
Thiamini mononitras ()
P&D ID
PD010200
CAS
108631-50-1
100660-17-1
59-43-8
67-03-8
70-16-6
532-43-4
Tags
available
drug
drug candidate
Approved by
FDA
First approval
1993
1982
1985
Drug indication
Discovery agent
Chronic kidney disease
anemia (phenotype)
Vitamin B1 deficiency
Heart disease
Drug Status
vet_approved
approved
investigational
nutraceutical
Max Phase
3.0
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.Thiamine hydrochloride activates NrF-2/HO-1 and inhibits TLR4, NF-¦ÊB. Thiamine hydrochloride has neuroprotective and anti-inflammatory effects. Thiamine hydrochloride can be used in the studys of diabetic complications, neurological diseases, cancers, and colitis[1][2][3][4][5][6][7].
PRICE
29
MOA
It is thought that the mechanism of action of thiamine on endothelial cells is related to a reduction in intracellular protein glycation by redirecting the glycolytic flux. Thiamine is mainly the transport form of the vitamin, while the active forms are phosphorylated thiamine derivatives. Natural derivatives of thiamine phosphate, such as thiamine monophosphate (ThMP), thiamine diphosphate (ThDP), also sometimes called thiamine pyrophosphate (TPP), thiamine triphosphate (ThTP), and thiamine triphosphate (AThTP), that act as coenzymes in addition to their each unique biological functions.
DESCRIPTION
Approved as a nutraceutical by the FDA as thiamine hydrochloride in 1972, no prior history available.
(GtoPdb)
PRICE
29
DESCRIPTION
Thiamine nitrate is an essential vitamin which can enhance normal neuronal actives.
PRICE
29
DESCRIPTION
Thiamine is a vitamin used to correct vitamin B1 deficiency. It plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine plays an important role in helping the body convert carbohydrates and fat into energy.
(Enamine Bioactive Compounds)
DESCRIPTION
Thiamine hydrochloride (Vitamin B1) is the hydrochloride salt form of thiamine, a vitamin essential for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis. Upon hydrolysis, Thiamine hydrochloride (Vitamin B1) is phosphorylated by thiamine diphosphokinase to form active thiamine pyrophosphate (TPP), also known as cocarboxylase. TPP is a coenzyme for many enzymatic activities involving fatty acid, amino acid and carbohydrate metabolism.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Thiamine monochloride (Vitamin B1) is an essential vitamin with erythropoietic, glucose-regulatory, antioxidant, and mood-regulatory properties. It inhibits lead-induced lipid peroxidation, preventing lead poisoning, and plays a crucial role in cellular energy production from ingested food while enhancing normal neuronal activity.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Thiamine nitrate (Vitamin B1 nitrate) is an essential vitamin, and can enhance normal neuronal actives.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
27
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
NCATS Inxight Approved Drugs
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
112
Molecular Weight
265.11
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
0.61
TPSA
75.91
Fraction CSP3
0.42
Chiral centers
0.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
Bacterial
antioxidant
Apoptosis
HBV
VB1
SLC19A2, SLC19A3, TPK1
Keap1-Nrf2
NF-κB
Toll-like Receptor (TLR)
Vitamin
MOA
Vitamin inhibitor
vitamin B
Indication
thiamine deficiency
Therapeutic Class
Vitamins
Pathway
Metabolism
Microbiology/virology
oxidation-reduction
Anti-infection
Metabolic Enzyme/Protease
Immunology/Inflammation
NF-¦ÊB
Source data
