General
Preferred name
CITRULLINE
Synonyms
L-CITRULLINE ()
L-Citrulline (DL-malate) ()
NSC-27425 ()
Citrulline malate (salt) ()
L-citrulline dl-malate ()
L-citrulline malate ()
Stimol ()
CITRULLINE MALATE ()
P&D ID
PD010197
CAS
627-77-0
13594-51-9
372-75-8
54940-97-5
70796-17-7
Tags
available
drug
endogenous
drug candidate
Approved by
FDA
Drug indication
Hypertension
Acute lung injury
Coronary artery disease
Drug Status
approved
nutraceutical
investigational
Max Phase
3.0
0.5
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
L-citrulline is a non-essential amino acid. Some mammalian proteins naturally contain citrulline residues (myelin basic protein, some histone proteins and filaggrin).
(GtoPdb)
PRICE
29
DESCRIPTION
L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway. It is used as a sports performance and cardiovascular health supplement.
(Enamine Bioactive Compounds)
DESCRIPTION
L-Citrulline, an amino acid, is derived from ornithine during the catabolism of proline, glutamate, or glutamine, and also from L-arginine via the arginine-citrulline pathway.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
19
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Concise Guide to Pharmacology 2025/26
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
Enamine Bioactive Compounds
Guide to Pharmacology
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
113
Molecular Weight
175.1
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
4
Rotatable Bonds
5
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.15
TPSA
118.44
Fraction CSP3
0.67
Chiral centers
1.0
Largest ring
0.0
QED
0.39
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
ASS1, DDAH1, DDAH2, GPRC6A, NOS1, NOS2, NOS3, OTC, PADI1, PADI2, PADI3, PADI4, PADI6
Disease Area
cardiology, urology
Indication
hypertension, erectile dysfunction
MOA
nitric oxide stimulant
Pathway
Metabolic Enzyme/Protease
Metabolism
Source data
