General
Preferred name
icosapent
Synonyms
Eicosapentaenoic Acid ()
DHA-metformin ()
EPA ()
Timnodonic acid ()
Eicosapentaenoic Acid-d5 ()
TP-252 ()
Eicosapentaenoic Acid (sodium salt) ()
Eicosapentaenoate ()
Incromega e 7010sr ()
Ropufa 70 ()
EPA 45G ()
Eicosapentaenoic acid (c20:5 n3) ()
All-cis-fatty acid 20:5 omega-3 ()
C20:5 (n-3) ()
Icosapento ()
Eicosapentaenoic Acid MaxSpec® Standard ()
Eicosapentaenoic Acid-d5 MaxSpec® Standard ()
Eicosapentaenoic Acid 1,2,3,4,5-13C ()
P&D ID
PD010195
CAS
10417-94-4
1197205-73-4
73167-03-0
Tags
available
drug
drug candidate
Approved by
FDA
Drug indication
Hypertriglyceridemia
Thrombin deficiency
prostate adenocarcinoma
Hyperglyceridemia
Drug Status
approved
investigational
nutraceutical
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (¦Ø-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein ¦Ä (C/EBP¦Ä). Eicosapentaenoic Acid activates RAS/ERK/C/EBP¦Â pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation[1][2][3].
PRICE
29
DESCRIPTION
Eicosapentaenoic Acid (EPA) is a ??-3 fatty acid abundantly available in marine organisms.
DESCRIPTION
Eicosapentaenoic Acid (EPA) is a ω-3 fatty acid abundantly available in marine organisms.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
20
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
69
Molecular Weight
302.22
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
13
Ring Count
0
Aromatic Ring Count
0
cLogP
5.99
TPSA
37.3
Fraction CSP3
0.45
Chiral centers
0.0
Largest ring
0.0
QED
0.33
QED
0.33
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
ACSL3, ACSL4, FADS1, FFAR1, PPARD, PPARG, PTGS1, PTGS2, SLC8A1, TRPV1
Histone Demethylase
Immunology & Inflammation related
Indication
hypertriglyceridemia
MOA
Platelet aggregation Inhibitor
Therapeutic Class
Dietary supplement
Pathway
Chromatin/Epigenetic
Metabolism
Epigenetics
Metabolic Enzyme/Protease
Source data
