General
Preferred name
BETAXOLOL
Synonyms
BETAXALOL HYDROCHLORIDE ()
BETAXOLOL HYDROCHLORIDE ()
levobetaxolol ()
SL75212 ()
Betaxolol HCl ()
SL 75212 HCl ()
Betaxolol (hydrochloride) ()
SL 75212,Dextrobetaxolol ()
Betaxolol ()
SL-75.212-10 ()
Betoptic S ()
ALO 1401-02 ()
SL-75212-10 ()
SL 75.212-10 ()
Kerlone ()
NSC-760048 ()
Betoptic ()
ALO-1401-02 ()
ALO-140102 ()
SL-7521210 ()
SL-7521210 FREE BASE ()
ALO-140102 FREE BASE ()
Betoptic Susp ()
Kerledex ()
Betaxolol-d7 (hydrochloride) ()
P&D ID
PD010175
CAS
63659-18-7
72424-72-7
63659-19-8
1219802-92-2
Tags
natural product
drug
available
Approved by
FDA
First approval
1985
Drug Status
investigational
approved
Drug indication
Hypertension
Antihypertensive
Anti-Anginal
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Betaxolol is a cardioselective β1-adrenoceptor antagonist. (GtoPdb)
DESCRIPTION Selective 5-HT2A antagonist. Also antagonist at 5-HT1D (Tocris Bioactive Compound Library)
DESCRIPTION Selective beta1 adrenoceptor antagonist (LOPAC library)
DESCRIPTION Selective β1 antagonist (Tocriscreen Total)
Cell lines
0
Organisms
1
Compound Sets
30
AdooQ Bioactive Compound Library
A11721
Cayman Chemical Bioactives
18625
26285
39815
ChEMBL Approved Drugs
CHEMBL1691
CHEMBL423
ChEMBL Drugs
CHEMBL1691
CHEMBL423
Concise Guide to Pharmacology 2017/18
549
Concise Guide to Pharmacology 2019/20
549
Concise Guide to Pharmacology 2021/22
549
Concise Guide to Pharmacology 2023/24
549
DrugBank
DB00195
DrugBank Approved Drugs
DB00195
DrugCentral
356
DrugCentral Approved Drugs
356
DrugMAP
DM6EUL5
DrugMAP Approved Drugs
DM6EUL5
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS101678
Guide to Pharmacology
549
Ki Database
BETAXOLOL
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL423
MedChem Express Bioactive Compound Library
HY-B0381A
HY-B0381
NCATS Inxight Approved Drugs
O0ZR1R6RZ2
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
betaxolol-hydrochloride-betoptic
betaxolol-betoptic
TargetMol Bioactive Compound Library
T0226
Tocris Bioactive Compound Library
0906
Tocriscreen Total
External IDs
63
Properties
(calculated by RDKit )
Molecular Weight
307.21
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
11
Ring Count
2
Aromatic Ring Count
1
cLogP
2.39
TPSA
50.72
Fraction CSP3
0.67
Chiral centers
1.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
beta1
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
??1-adrenergic receptor
Adrenergic Receptor
Primary Target
Adrenergic ?1 Receptors
MOA
Antagonist
Therapeutic Class
Antihypertensive Agents
Source data