General
Preferred name
GUANADREL
Synonyms
Hylorel ()
CL-1388R ()
U-28288D ()
Guanadrel sulfate ()
Guanadrel hydroiodide ()
Guanadrel sulphate ()
NSC-760062 ()
U-28,288D ()
P&D ID
PD010159
CAS
22195-34-2
40580-59-4
1443980-00-4
Tags
available
drug
Approved by
FDA
First approval
1982
Drug indication
Hypertension
Drug Status
approved
withdrawn
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Guanadrel is an adrenergic neuron inhibitor that slowly displaces norepinephrine from its storage in nerve endings. It blocks the release of norepinephrine in response to the sympathetic nerve stimulation, leading to reduced arteriolar vasoconstriction, especially the reflex increase in sympathetic tone that occurs with a change in position.
DESCRIPTION
Guanadrel is a postganglionic adrenergic blocking drug.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
58
Molecular Weight
213.15
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
0
cLogP
0.55
TPSA
80.36
Fraction CSP3
0.9
Chiral centers
1.0
Largest ring
6.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
norepinephrine transporter substrate
Target
Norepinephrine transporter
Adrenergic Receptor
ATC
N
Therapeutic Class
Antihypertensive Agents
Pathway
GPCR/G protein
Neuronal Signaling
Source data
