General
Preferred name
CEFOTIAM
Synonyms
SCE-963 hydrochloride ()
Cefotiam dihydrochloride ()
Halospor ()
Pansporin ()
Pansporine ()
CEFOTIAM HYDROCHLORIDE ()
Cefotiam ()
Cefotiam (hydrochloride) ()
Cefotiam dihydrochloride hydrate ()
SCE-963 (hydrochloride) ()
Cefotiam dihydrochloride, Halospor, Pansporin, Pansporine ()
Cefotiam Hexetil Hydrochloride ()
ABBOTT-48999 ()
SCE 963 ()
Cefotiam hcl ()
NSC-758164 ()
Ceradon ()
CGP-14221/E ()
SCE-963 ()
Aspil ()
J01DC07 ()
Cefotiam (hydrochloride hydrate) ()
P&D ID
PD010157
CAS
66309-69-1
61622-34-2
Tags
natural product
drug
available
Approved by
FDA
Drug Status
investigational
approved
withdrawn
Drug indication
Antibacterial
Respiratory tract infection
Max Phase
Phase 4
First approval
1988
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS
Cefotiam is a third generation beta-lactam cephalosporin antibiotic that works by inhibiting bacterial cell wall biosynthesis. It is a broad spectrum antibiotic that is effective against Gram positive and Gram negative bacteria.
DESCRIPTION
Cefotiam is a second generation cephalosporin, belonging to the β-lactam class of antibacterial compounds.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
19
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Natural product-based probes and drugs
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
61
Molecular Weight
525.1
Hydrogen Bond Acceptors
13
Hydrogen Bond Donors
3
Rotatable Bonds
10
Ring Count
4
Aromatic Ring Count
2
cLogP
-0.65
TPSA
172.46
Fraction CSP3
0.5
Chiral centers
2.0
Largest ring
6.0
QED
0.26
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology&virology
Anti-infection
Target
PBPs
antibiotic
Bacterial
Indication
bacterial septicemia, bone and joint infections, respiratory tract infections, skin infections, urinary tract infections
MOA
bacterial cell wall synthesis inhibitor
ATC
J01DC07
Biosynthetic Origin
Peptide (beta-Lactam)
Therapeutic Indication
Antibacterial
Therapeutic Class
Antimicrobial
Antibiotics
Source data
