General
Preferred name
cabergoline
Synonyms
FCE-21336 ()
Dostinex ()
CABASER ()
FCE 21336 ()
VELACTIS ()
CABERGOLINA ()
Cabergoline-d6 ()
P&D ID
PD010146
CAS
81409-90-7
2738376-76-4
Tags
available
drug
biased GPCR ligand
Approved by
PMDA
FDA
First approval
1996
Drug indication
Infertility
Hyperprolactinaemia
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Cabergoline is an ergot-derived, long-acting dopamine receptor agonist (dopamine D2 receptor) and prolactin inhibitor. (GtoPdb)
DESCRIPTION Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).
PRICE 165
DESCRIPTION Cabergoline (FCE-21336) is an ergot derived-dopamine D2-like receptor agonist. It has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).Cabergoline permits rapid and effective hormonal and tumor control by normalizing prolactin-producing pituitary adenomas levels. (TargetMol Bioactive Compound Library)
Compound Sets
26
BiasDB
Cabergoline
Cayman Chemical Bioactives
23934
31690
ChEMBL Approved Drugs
CHEMBL1201087
ChEMBL Drugs
CHEMBL1201087
Concise Guide to Pharmacology 2017/18
37
Concise Guide to Pharmacology 2019/20
37
Concise Guide to Pharmacology 2021/22
37
Concise Guide to Pharmacology 2023/24
37
Drug Repurposing Hub
DrugBank
DB00248
DrugBank Approved Drugs
DB00248
DrugCentral
460
DrugCentral Approved Drugs
460
DrugMAP
DMQ4HIN
DrugMAP Approved Drugs
DMQ4HIN
EUbOPEN Chemogenomics Library
EUB0000787
Guide to Pharmacology
37
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1201087
MedChem Express Bioactive Compound Library
HY-15296
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
LL60K9J05T
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
cabergoline
TargetMol Bioactive Compound Library
T14853
External IDs
43
Properties
(calculated by RDKit )
Molecular Weight
451.29
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
2
cLogP
3.19
TPSA
71.68
Fraction CSP3
0.54
Chiral centers
3.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
member
MOA
Dopamine D2 Agonists
Prolactin Secretion Inhibitors
Dopamine Receptor agonist
Target
ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7
Dopamine Receptor
5-HT2B
D2
D3
dopamine
Indication
hyperprolactinemia
Pathway
Autophagy
GPCR/G protein
Neuroscience
Neuronal Signaling
Biosynthetic Origin
Alkaloid
Therapeutic Indication
Antihyperprolactinemia
Therapeutic Class
CNS & PNS
Anticancer Agents
Recommended Cell Concentration
100 nM
Source data