General
Preferred name
cabergoline
Synonyms
FCE-21336 ()
Dostinex ()
FCE 21336 ()
Cabaser ()
Velactis ()
Cabergoline-d6 ()
P&D ID
PD010146
CAS
81409-90-7
2738376-76-4
Tags
drug
natural product
biased GPCR ligand
available
Approved by
PMDA
FDA
First approval
1996
Drug Status
approved
Drug indication
Antihyperprolactinemic
Hyperprolactinaemia
Dopamine Agonist
Antidyskinetic
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Cabergoline is an ergot-derived, long-acting dopamine receptor agonist (dopamine D2 receptor) and prolactin inhibitor.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
25
BiasDB
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
38
Molecular Weight
451.29
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
2
cLogP
3.19
TPSA
71.68
Fraction CSP3
0.54
Chiral centers
3.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuroscience
Autophagy
Neuronal Signaling
Target
D2
D3
5-HT2B
ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7
Dopamine Receptor
Member status
member
MOA
Dopamine D2 Agonists
Prolactin Secretion Inhibitors
Dopamine Receptor agonist
Indication
hyperprolactinemia
Biosynthetic Origin
Alkaloid
Therapeutic Indication
Antihyperprolactinemia
Therapeutic Class
CNS & PNS
Anticancer Agents
Source data
