General
Preferred name
PYRIDOSTIGMINE
Synonyms
PYRIDOSTIGMINE BROMIDE ()
Pyridostigmine (D6 bromide) ()
mestinon ()
Pyridostigmine iodide ()
Lefaxin ()
Pyridostigmine (bromide) ()
Regonol ()
Pyridostigmini bromidum ()
NSC-679759 ()
NSC-758435 ()
RO-1-5130 ()
Kalimin ()
Mestinon Ret ()
Regonal ()
Kalymin ()
Mestinon 10 ()
Pyridostigmine cation ()
Pyridostigmine ion ()
Pyridostigmine-d3 (bromide) ()
P&D ID
PD010140
CAS
4685-03-4
101-26-8
155-97-5
Tags
available
drug
Approved by
FDA
First approval
1955
Drug Status
investigational
approved
Drug indication
Myasthenia gravis
Discovery agent
Cholinergic
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Pyridostigmine is a peripherally acting, orally active reversible acetylcholinesterase (ACHE) inhibitor, with a slightly longer duration of action than . Marketed formulations contain pyridostigmine bromide (PubChem CID 7550). (GtoPdb)
DESCRIPTION Cholinesterase inhibitor (LOPAC library)
DESCRIPTION Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor. (BOC Sciences Bioactive Compounds)
Compound Sets
29
BOC Sciences Bioactive Compounds
pyridostigmine-bromide-cas-101-26-8-item-84-52993
Cayman Chemical Bioactives
23831
35208
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL812
CHEMBL1115
ChEMBL Drugs
CHEMBL812
CHEMBL1115
Drug Repurposing Hub
DrugBank
DB00545
DrugBank Approved Drugs
DB00545
DrugCentral
2330
DrugCentral Approved Drugs
2330
DrugMAP
DM0CEY3
DM8HO1L
DrugMAP Approved Drugs
DM8HO1L
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100982
Guide to Pharmacology
8994
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1115
MedChem Express Bioactive Compound Library
HY-B0207A
NCATS Inxight Approved Drugs
19QM69HH21
NIH Clinical Collections (NCC)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Pyridostigmine-Bromide(Mestinon)
TargetMol Bioactive Compound Library
T0780
The Spectrum Collection
ZINC Tool Compounds
ZINC000000002009
External IDs
70
Properties
(calculated by RDKit )
Molecular Weight
181.1
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
0.57
TPSA
33.42
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.59
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Cholinesterase
Target
AChE
Acetylcholinesterase
ACHE, BCHE
Cholinesterase (ChE)
AChR
Pathway
Neuronal Signaling
Neuroscience
MOA
Acetylcholinesterase inhibitor
cholinesterase inhibitor
Indication
myasthenia gravis
Therapeutic Class
Parasympathomimetics
Source data