General
Preferred name
PAMIDRONIC ACID
Synonyms
Pamidronate (Disodium) ()
CGP 23339A ()
Pamidronate disodium salt ()
CGP 23339AE ()
PAMIDRONATE DISODIUM ()
Pamidronate ()
Pamidronate (disodium pentahydrate) ()
Disodium pamidronate ()
Pamidronate disodium pentahydrate ()
Pamidronate (sodium salt) ()
Aredia ()
CGP-23339AE ()
Pamidronate disodium hydrate ()
Ribodroat ()
Acide pamidronique ()
Acido pamidronico ()
P&D ID
PD010127
CAS
109552-15-0
57248-88-1
40391-99-9
1159812-33-5
Tags
available
drug
Approved by
FDA
First approval
1991
Drug indication
Hypercalcaemia
Multiple myeloma
Bone disease
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/??-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells
PRICE
39
DESCRIPTION
Pamidronic acid is a bisphosphonate drug.
(GtoPdb)
PRICE
29
DESCRIPTION
Pamidronate disodium pentahydrate is a nitrogen-containing bisphosphonate, used to prevent osteoporosis.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells
(TargetMol Bioactive Compound Library)
DESCRIPTION
Pamidronic acid (INN) or pamidronate disodium (USAN), pamidronate disodium pentahydrate is a nitrogen-containingbisphosphonate, used to prevent osteoporosis.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Pamidronate Disodium (CGP 23339A), a nitrogen-containing bisphosphonate, can help to strengthen bones.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Pamidronic acid is a second generation, nitrogen containing bisphosphonate that inhibits osteoclast mediated bone loss. It is used to treat Paget's disease, to treat hypercalcemia of malignancy, and to treat osteolytic bone lesions.
(Enamine Bioactive Compounds)
DESCRIPTION
Pamidronate disodium pentahydrate is a bone resorption inhibitor, a compound capable of preventing osteoporosis.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
4
Organisms
3
Compound Sets
32
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
NCATS Inxight Approved Drugs
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
85
Molecular Weight
235.0
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
6
Rotatable Bonds
4
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.66
TPSA
161.31
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
0.0
QED
0.32
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
¦Â-catenin
Farnesyl diphosphate synthase
Wnt
β-catenin
FPPS
HAP
??catenin
FDPS
RANKL/RANK
Toll-like Receptor (TLR)
MOA
osteoclastic proton pump inhibitor
protein-tyrosine phosphatase inhibitor
HBV
Farnesyl Pyrophosphate Synthase Inhibitors
bone resorption inhibitor
Member status
member
Indication
hypercalcemia, Paget's disease, breast cancer, multiple myeloma
Disease Area
endocrinology, oncology, hematologic malignancy
Therapeutic Class
Antiinflammatory Agents
Pathway
Cytoskeletal Signaling
Stem Cells
Microbiology/virology
Immunology/Inflammation
NF-κB
Stem Cell/Wnt
Source data
