General
Preferred name
AMCINONIDE
Synonyms
CL-34699 ()
Cyclocort, CL-34699 ()
CL 34699 ()
NSC-758620 ()
Amcinonida ()
Cyclocort ()
P&D ID
PD010122
CAS
51022-69-6
Tags
available
drug
Approved by
FDA
First approval
1979
Drug indication
Inflammation
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
ROE
Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. ; Some of the topical corticosteroids and their metabolites are also excreted into the bile.
DESCRIPTION
Amcinonide is a NO inhibitor that inhibits NO release from activated microglia with IC50 of 3.38 nM. Amcinonide has glucocorticoid receptor affinity[1].
PRICE
29
DESCRIPTION
A topically applied corticosteroid.
(GtoPdb)
DESCRIPTION
Amcinonide (CL-34699) is a Corticosteroid. The mechanism of action of amcinonide is as a Corticosteroid Hormone Receptor Agonist.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
30
Molecular Weight
502.24
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
6
Aromatic Ring Count
0
cLogP
3.52
TPSA
99.13
Fraction CSP3
0.75
Chiral centers
8.0
Largest ring
6.0
QED
0.59
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Annexin A1
Glucocorticoid Receptor
Interleukin Related
NO Synthase
TNF Receptor
NOS
Therapeutic Class
Antiinflammatory Agents
Pathway
Apoptosis
Immunology/Inflammation
Vitamin D Related/Nuclear Receptor
Endocrinology/Hormones
GPCR/G protein
Source data
