General
Preferred name
TALBUTAL
Synonyms
Talbutal ()
Lotusate ()
P&D ID
PD010111
CAS
115-44-6
Tags
natural product
drug
Approved by
FDA
Drug Status
illicit
approved
withdrawn
Drug indication
Irritability
Max Phase
Phase 4
First approval
1982
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Talbutal is a short to intermediate-acting barbiturate that is a nonselective central nervous system (CNS) depressant. As with other barbiturates, talbutal is capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. Barbiturates may also induce anesthesia at sufficiently high therapeutic doses.
MOA Talbutal binds to GABAA receptors at a distinct binding site associated with a Cl- ionopore of the receptor. Upon binding, talbutal increases the duration of time for which the Cl- ionopore is open, leading to prolonged inhibitory effect of GABA at the postsynaptic thalamic neuron.
TOXICITY Acute barbiturate poisoning is associated with symptoms such as drowsiness, confusion, coma, respiratory depression, hypotension, and shock.
Compound Sets
10
ChEMBL Approved Drugs
CHEMBL1200802
ChEMBL Drugs
CHEMBL1200802
DrugBank
DB00306
DrugBank Approved Drugs
DB00306
DrugCentral
2556
DrugCentral Approved Drugs
2556
DrugMAP
DM214Q8
DrugMAP Approved Drugs
DM214Q8
DrugMatrix
Withdrawn 2.0
156
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
224.12
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
0
cLogP
0.96
TPSA
75.27
Fraction CSP3
0.55
Chiral centers
1.0
Largest ring
6.0
QED
0.55
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
ATC
N05CA07
Therapeutic Class
Hypnotics and Sedatives
Source data