General
Preferred name
IBUTILIDE
Synonyms
Ibutilide hemifumarate ()
U-70226E ()
Corvert ()
U70226E ()
Corvert Fumarate ()
Ibutilide Fumarate ()
Ibutilide hemifumarate ()
Ibutilide (fumarate) ()
2016-03-02: ibutilide fumarate ()
U-70226E,Corvert Fumarate ()
(±)-Ibutilide (hemifumarate) ()
P&D ID
PD010110
CAS
122647-32-9
122647-31-8
100632-81-3
Tags
natural product
drug
available
Approved by
FDA
First approval
1995
Drug Status
approved
Drug indication
Cardiac Depressant (anti-arrhythmic)
Atrial fibrillation
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ibutilide is an antiarrhythmic drug.
Marketed formulations may contain ibutilide fumarate (PubChem CID 6437366). (GtoPdb)
DESCRIPTION TRPA1 blocker (Tocris Bioactive Compound Library)
DESCRIPTION Blocks IKr, hERG and L-type Ca2+ channels; class III antiarrhythmic (Tocriscreen Plus)
Compound Sets
31
AdooQ Bioactive Compound Library
A11750
Cayman Chemical Bioactives
15011
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL2355456
CHEMBL533
ChEMBL Drugs
CHEMBL2355456
CHEMBL533
Concise Guide to Pharmacology 2017/18
7200
Concise Guide to Pharmacology 2019/20
7200
Concise Guide to Pharmacology 2021/22
7200
Concise Guide to Pharmacology 2023/24
7200
DrugBank
DB00308
DrugBank Approved Drugs
DB00308
DrugCentral
1412
DrugCentral Approved Drugs
1412
DrugMAP
DMKXY2R
DrugMAP Approved Drugs
DMKXY2R
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
7200
JUMP-Target 1 Compound Set
60753
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL533
MedChem Express Bioactive Compound Library
HY-B0387
NCATS Inxight Approved Drugs
2436VX1U9B
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
ibutilide-fumarate
TargetMol Bioactive Compound Library
T6541
Tocris Bioactive Compound Library
3908
Tocriscreen Plus
3908
External IDs
61
Properties
(calculated by RDKit )
Molecular Weight
384.24
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
14
Ring Count
1
Aromatic Ring Count
1
cLogP
4.16
TPSA
69.64
Fraction CSP3
0.7
Chiral centers
1.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
MOA
voltage-gated potassium channel blocker
Potassium Channel Blockers
Antiarrhythmic
Target
HERG
Sodium Channel
KCNK1
Potassium Channel
Pathway
Membrane Transporter/Ion Channel
Primary Target
Other Channel Modulators
Member status
member
Therapeutic Class
Antiarrhythmic Agents
Source data