General
Preferred name
fluorometholone
Synonyms
Fluoromethalone ()
Cortilet ()
Oxylone ()
Delmeson ()
fluorometholone, Allergan ()
Fluorometholone component of fml-s ()
Fml Fte ()
Fluorometolona ()
Fluor-Op ()
NSC-33001 ()
Fml Forte ()
Fml ()
Fml-Neo ()
Fluaton ()
P&D ID
PD010100
CAS
426-13-1
Tags
available
drug
Approved by
FDA
First approval
1972
Drug indication
Chronic obstructive pulmonary disease
acne
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Fluorometholone, a synthetic glucocorticoid, is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic properties. Fluorometholone can be used for the research of dry eye[1].
DESCRIPTION
Fluorometholone is a corticosteroid.
(GtoPdb)
DESCRIPTION
Fluorometholone (Fluoromethalone) is a corticosteroid, most often used after laser-based refractive surgery. It is marketed under the brand names FML (Allergan) and Flarex (Alcon). Fluorometholone acetate ophthalmic suspension is indicated for use in the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
19
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
36
Molecular Weight
376.2
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
0
cLogP
2.92
TPSA
74.6
Fraction CSP3
0.73
Chiral centers
8.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Glucocorticoid Receptor
NR3C1
Indication
eye inflammation
MOA
Glucocorticoid Receptor agonist
Therapeutic Class
Antiallergic Agents
Pathway
Immunology/Inflammation
Vitamin D Related/Nuclear Receptor
Endocrinology/Hormones
Source data
