General
Preferred name
METHADONE
Synonyms
Methadone,(S)(+) ()
Methadone,(R)(-) ()
Methadone-HCL,(-) ()
METHADONE HYDROCHLORIDE ()
Phenadone ()
Phy ()
Dolophin ()
Diaminon ()
Metasedin ()
Heptadone ()
IDS-NM-002 ()
Metadona ()
Amidone ()
Dl-methadone ()
Symoron ()
Metharose ()
Martindale ()
Synastone ()
AN-148 ()
Dolofin hydrochloride ()
Dolophine hydrochloride ()
Pinadone ()
Butalgin ()
Dolophine ()
Methadone Hydrochloride Intensol ()
Westadone ()
Heptadon ()
Fenadone ()
NSC-19600 ()
Methadone hcl ()
Methex ()
Eptadone ()
Methadose ()
Methadone hydrochloride cii ()
Ketalgin hydrochloride ()
Phenadone hydrochloride ()
Adanon hydrochloride ()
Mecodin ()
Physeptone ()
(±)-Methadone (hydrochloride) ()
(±)-Methadone-d9 ()
3-azido-7-hydroxy Coumarin ()
(±)-Methadone-d3 ()
(±)-Methadone-d9 (CRM) ()
P&D ID
PD010093
CAS
297-88-1
76-99-3
1095-90-5
1435933-74-6
817638-68-9
60263-63-0
Tags
available
drug
Approved by
FDA
First approval
1947
Drug indication
Dry cough
HIV infection
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
ROE The elimination of methadone is mediated by extensive biotransformation, followed by renal and fecal excretion. ; Unmetabolized methadone and its metabolites are excreted in urine to a variable degree.
DESCRIPTION The approved drug methadone is a racemic mixture of two enantiomers; (S)-methadone and (R)-methadone. The structure shown here does not specify stereochemistry and represents the mixture. (GtoPdb)
Compound Sets
18
Cayman Chemical Bioactives
37451
10596
15825
39479
39396
ChEMBL Approved Drugs
CHEMBL651
CHEMBL1200825
ChEMBL Drugs
CHEMBL651
CHEMBL1200825
Concise Guide to Pharmacology 2017/18
5458
Concise Guide to Pharmacology 2019/20
5458
Concise Guide to Pharmacology 2021/22
5458
Concise Guide to Pharmacology 2023/24
5458
DrugBank
DB00333
DrugBank Approved Drugs
DB00333
DrugCentral
1728
DrugCentral Approved Drugs
1728
DrugMAP
DMTW6IU
DrugMAP Approved Drugs
DMTW6IU
DrugMatrix
Guide to Pharmacology
5458
Ki Database
Methadone
Methadone,(R)(-)
Methadone,(S)(+)
Methadone-HCL,(-)
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL651
NCATS Inxight Approved Drugs
UC6VBE7V1Z
External IDs
59
Properties
(calculated by RDKit )
Molecular Weight
309.21
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
2
cLogP
4.29
TPSA
20.31
Fraction CSP3
0.38
Chiral centers
1.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Therapeutic Class
Analgesics
Source data