General
Preferred name
metixene
Synonyms
METHIXENE ()
Metixene hydrochloride ()
Metixene (hydrochloride hydrate) ()
Metixene hydrochloride hydrate ()
METHIXENE HYDROCHLORIDE ()
NSC-78194 ()
SJ 1977 ()
Trest ()
Methixene hydrochloride anhydrous ()
Tremarit ()
Tremonil ()
Tremaril ()
SJ-1977 ()
Anhydrous metixene hydrochloride ()
Metixen ()
Methixene hcl ()
Metixene hydrochloride anhydrous ()
Metixeno ()
Atosil ()
Metixene ()
P&D ID
PD010091
CAS
1553-34-0
7081-40-5
4969-02-2
96106-76-2
115511-20-1
Tags
available
drug
Approved by
FDA
Drug indication
Parkinson disease
Drug Status
approved
withdrawn
Max Phase
4.0
First approval
1982
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Metixene (Piperidine) hydrochloride hydrate is an anticholinergic and antiparkinsonian agent. Metixene hydrochloride hydrate potently inhibits binding of quinuclidinyl benzilate (QNB) with the muscarinic receptor, IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene hydrochloride hydrate can be used for the research of parkinsonian[1][2][3].
PRICE
44
DESCRIPTION
Methixene is an antihistamine drug, with anticholinergic activity. There is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation.
(GtoPdb)
DESCRIPTION
Metixene hydrochloride hydrate has potential anticholinergic activity and inhibits the binding of quinine ring benzoate (QNB) to muscarine receptors, with IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene hydrochloride hydrate can be used to prevent and treat Parkinson's disease.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
17
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
52
Molecular Weight
309.16
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
2
cLogP
5.02
TPSA
3.24
Fraction CSP3
0.4
Chiral centers
1.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
mAChR
Cholinergic
ATC
N04AA03
Pathway
Neuroscience
GPCR/G protein
Neuronal Signaling
Therapeutic Class
Antiparkinson Agents
Source data
