General
Preferred name
NITISINONE
Synonyms
NTBC ()
SC0735 ()
Nitisone ()
NTBC, Nitisone, SC0735 ()
Orfadin ()
Nitisinone mdk (previously nitisinone mendelikabs) ()
Nitisinona ()
SC-0735 ()
Nityr ()
Nitisinone-13C6 ()
P&D ID
PD010088
CAS
104206-65-7
1246815-63-3
Tags
available
drug
Approved by
EMA
FDA
First approval
2002
Drug indication
Hereditary tyrosinemia type 1
tyrosinemia
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Inhibits 4-hydroxyphenylpyruvate dioxygenase (HPD)
(GtoPdb)
DESCRIPTION
Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC50 of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism[1][2][3][4].
PRICE
32
DESCRIPTION
Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1.
(Enamine Bioactive Compounds)
DESCRIPTION
Nitisinone (SC0735)(SC0735) is an enzyme 4-hydroxyphenylpyruvate dioxygenase inhibitor.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
25
AdooQ Bioactive Compound Library
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
41
Molecular Weight
329.05
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
2.73
TPSA
94.35
Fraction CSP3
0.36
Chiral centers
0.0
Largest ring
6.0
QED
0.37
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
NF-¦ÊB
Metabolic Enzyme/Protease
Immunology/Inflammation
Metabolism
NF-κB
MOA
4-hydroxyphenylpyruvate dioxygenase inhibitor
4-Hydroxyphenylpyruvate Dioxygenase (4HPPD) Inhibitors
Target
4-hydroxyphenylpyruvate dioxygenase
Reactive Oxygen Species
HPPD
Member status
member
Therapeutic Class
Anticancer Agents
Source data
