General
Preferred name
AZTREONAM
Synonyms
SQ-26,776 ()
aztreonam lysine, Gilead ()
AZTREONAM LYSINE ()
SQ 26776 ()
NSC-646279 ()
Aztreon ()
Azonam ()
NSC-758913 ()
Nebactam ()
SQ-26776 ()
Cayston ()
SO 26776 ()
Azactam ()
Primbactam ()
CORUS-1020 ()
CORUS1020 ()
Corus 1020 ()
Aztreonam lysinate ()
Aztreonam l-lysine salt ()
Aztreonam-d6 ()
P&D ID
PD010083
CAS
78110-38-0
827021-54-5
827611-49-4
1127452-94-1
Tags
covalent binder
drug candidate
natural product
drug
available
Approved by
EMA
FDA
First approval
1986
Drug Status
investigational
approved
Drug indication
Bacterial infection
Antimicrobial
Max Phase
Phase 2
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Aztreonam is a monocyclic β-lactam antibacterial that is resistant to β-lactamase hydrolysis. It was isolated from Chromobacterium violaceum. Functionally it preferentially binds to and inactivates penicillin-binding protein-3 (PBP-3) and thereby inhibits bacterial cell wall synthesis. Aztreonam was removed from the World Health Organization's List of Essential Medicines in 2019. (GtoPdb)
Compound Sets
21
AdooQ Bioactive Compound Library
A10118
Cayman Chemical Bioactives
19784
28799
ChEMBL Approved Drugs
CHEMBL158
ChEMBL Drugs
CHEMBL158
CHEMBL3833340
CovBinderInPDB
CBR001154
CBR001344
CBR001345
CBR003141
CBR005527
CBR005808
CBR005809
CBR006168
CBR006240
CBR006244
CBR006899
Drug Repurposing Hub
DrugBank
DB00355
DrugBank Approved Drugs
DB00355
DrugCentral
279
DrugCentral Approved Drugs
279
DrugMAP
DMDNJHG
DrugMAP Approved Drugs
DMDNJHG
EU-OPENSCREEN Bioactive Compound Library
EOS100698
Guide to Pharmacology
10763
MedChem Express Bioactive Compound Library
HY-B0129
NCATS Inxight Approved Drugs
G2B4VE5GH8
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Aztreonam(Azactam)
TargetMol Bioactive Compound Library
T1029
External IDs
50
Properties
(calculated by RDKit )
Molecular Weight
435.05
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
4
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
1
cLogP
-1.17
TPSA
201.58
Fraction CSP3
0.46
Chiral centers
2.0
Largest ring
5.0
QED
0.17
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology&virology
Anti-infection
Target
PBPs
??-Lactamase
antibiotic
Bacterial
Penicillin-binding protein (PBP)
Antibiotics,Bacterial
Indication
urinary tract infections, respiratory tract infections, bacterial septicemia, skin infections, intra-abdominal infections, gynecologic infections
MOA
bacterial cell wall synthesis inhibitor
Therapeutic Class
Antibiotics
Source data