General
Preferred name
AZTREONAM
Synonyms
SQ-26,776 ()
aztreonam lysine, Gilead ()
SQ 26776 ()
AZTREONAM LYSINE ()
Primbactam ()
SO 26776 ()
Azonam ()
Aztreon ()
SQ-26776 ()
Azactam ()
NSC-758913 ()
Nebactam ()
NSC-646279 ()
Aztreonam l-lysine salt ()
Corus 1020 ()
CORUS1020 ()
CORUS-1020 ()
Aztreonam lysinate ()
Cayston ()
Aztreonam-d6 ()
P&D ID
PD010083
CAS
78110-38-0
827021-54-5
827611-49-4
1127452-94-1
Tags
available
drug
covalent binder
Approved by
EMA
FDA
First approval
2009
1986
Drug indication
Bronchiectasis
Pneumonia
Bacterial infection
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Aztreonam is a monocyclic β-lactam antibacterial that is resistant to β-lactamase hydrolysis. It was isolated from Chromobacterium violaceum. Functionally it preferentially binds to and inactivates penicillin-binding protein-3 (PBP-3) and thereby inhibits bacterial cell wall synthesis. Aztreonam was removed from the World Health Organization's List of Essential Medicines in 2019. (GtoPdb)
PRICE 29
DESCRIPTION Aztreonam (SQ-26,776) is a synthetic monocyclic beta-lactam antibiotic, which has a very high affinity for penicillin-binding protein 3 (PBP-3).
DESCRIPTION Aztreonam is a synthetic monocyclic beta-lactam antibiotic, which has a very high affinity for penicillin-binding protein 3. It is used to treat Gram-negative aerobic bacteria infection. (Enamine Bioactive Compounds)
DESCRIPTION Aztreonam (SQ-26,776), a monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum, possesses bactericidal activity. (TargetMol Bioactive Compound Library)
Compound Sets
23
AdooQ Bioactive Compound Library
A10118
Cayman Chemical Bioactives
19784
28799
ChEMBL Approved Drugs
CHEMBL158
CHEMBL3833340
ChEMBL Drugs
CHEMBL158
CHEMBL3833340
CovBinderInPDB
CBR001154
CBR001344
CBR001345
CBR003141
CBR005527
CBR005808
CBR005809
CBR006168
CBR006240
CBR006244
CBR006899
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00355
DrugBank Approved Drugs
DB00355
DrugCentral
279
DrugCentral Approved Drugs
279
DrugMAP
DMDNJHG
DrugMAP Approved Drugs
DMDNJHG
Enamine Bioactive Compounds
EBC-27089
EU-OPENSCREEN Bioactive Compound Library
EOS100698
Guide to Pharmacology
10763
MedChem Express Bioactive Compound Library
HY-B0129
NCATS Inxight Approved Drugs
G2B4VE5GH8
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Aztreonam(Azactam)
TargetMol Bioactive Compound Library
T1029
External IDs
52
Properties
(calculated by RDKit )
Molecular Weight
435.05
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
4
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
1
cLogP
-1.17
TPSA
201.58
Fraction CSP3
0.46
Chiral centers
2.0
Largest ring
5.0
QED
0.17
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Bacterial
PBPs
β-Lactamase
Penicillin-binding protein (PBP)
Antibiotics,Bacterial
Indication
urinary tract infections, respiratory tract infections, bacterial septicemia, skin infections, intra-abdominal infections, gynecologic infections
MOA
bacterial cell wall synthesis inhibitor
Pathway
Microbiology/virology
Anti-infection
Therapeutic Class
Antibiotics
Source data