General
Preferred name
phenylephrine
Synonyms
PHENYLEPHRINE HYDROCHLORIDE ()
(R)-(-)-Phenylephrine ()
L-Phenylephrine ()
(R)-(-)-Phenylephrine hydrochloride ()
Mezaton ()
Phenylephrine (hydrochloride) ()
Phenylephrine (NCI-C55641) HCl ()
NCI-c55641,Phenylephrine hydrochloride,(R)-(-)-Phenylephrine hydrochloride, L-Phenylephrine hydrochloride ()
(R)-(-)-Phenylephrine (hydrochloride) ()
L-Phenylephrine (hydrochloride) ()
(-)-PHENYLEPHRINE ()
(R)-PHENYLEPHRINE ()
AB-101 (PHENYLEPHRINE) ()
Cyclomydril ()
Duo-Medihaler ()
FENILEFRINA ()
J8.601K ()
M-OXEDRINE ()
M-SYMPATHOL ()
M-SYMPATOL ()
M-SYNEPHRINE ()
META-SYNEPHRINE ()
METASYNEPHRINE ()
PHENYLEPHRINE MINIMS ()
PHENYLEPHRINE, (R)- ()
R(-)-MEZATON ()
Phenylephrine hydrochloride component of pherazine vc ()
Afrin 4 hour nasal spray ()
Fenox ()
Phenylephrine hydrochloride component of advil congestion relief ()
Mydfrin ()
Prefrin ()
Nazex ()
Phenylephrine hydrochloride component of phenergan vc ()
Neosynephrine ()
Biorphen ()
Nurofen Sinus Pain Relief ()
Nostril ()
Fenilfar ()
Phenylephrine hydrochloride component of prefrin-a ()
Phenylephrine hydrochloride component of mydcombi ()
Vazculep ()
Neo-synephrine ()
Immphentiv ()
Phenylephrine hydrochloride component of promethazine vc ()
Phenylephrine hydrochloride component of cyclomydril ()
Phenylephrine hydrochloride component of omidria ()
NSC-757273 ()
Phenylephrine bitartrate component of duo-medihaler ()
Phenylephrine hydrogen tartrate ()
Phenylephrine acid tartrate ()
PHENYLEPHRINE BITARTRATE ()
P&D ID
PD010076
CAS
61-76-7
50741-76-9
1416-03-1
59-42-7
1228015-39-1
Tags
available
drug
biased GPCR ligand
Approved by
FDA
First approval
1973
1952
Drug indication
Common cold
Ophthalmic graves disease
Cardiovascular disease
cardiac arrhythmia
Fecal incontinence
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
(R)-(-)-Phenylephrine hydrochloride is a selective ¦Á1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for ¦Á1D, ¦Á1B and ¦Á1A receptors respectively.
DESCRIPTION
Marketed formulations may contain phenylephrine hydrochloride (PubChem CID 5284443).
(GtoPdb)
METABOLISM
Undergoes extensive first-pass metabolism in the intestinal wall and extensive metabolism in the liver. Sulfate conjugation, primarily in the intestinal wall, and oxidative metabolism by monoamine oxidase (MAO) represent the principle routes of metabolism. Glucuronidation occurs to a lesser extent. Phenylephrine and its metabolites are mainly excreted in urine/; .
DESCRIPTION
(R)-(-)-Phenylephrine is a selective ¦Á1-adrenoceptor agonist primarily used as a decongestant.
PRICE
29
DESCRIPTION
Phenylephrine ((R)-(-)-Phenylephrine) is a selective ??1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for ??1D, ??1B, and ??1A receptors respectively).
DESCRIPTION
5-HT4 agonist and 5-HT3 antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
alpha1 Adrenoceptor agonist; mydriatic; decongestant
(LOPAC library)
DESCRIPTION
Phenylephrine is an alpha-1 adrenergic agonist that mediates vasoconstriction and mydriasis depending on the route and location of administration. It is used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics.
(Enamine Bioactive Compounds)
DESCRIPTION
L-Phenylephrine is an α1 adrenergic receptor agonist (Ki = 1.4 µM) with selectivity for α1A over α1B and α1C receptor subtypes (Ki = 1.4, 23.9 and 47.8 µM, respectively). L-Phenylephrine has been used as a cardiotonic drug, mydriatic agent, vasoconstrictor agent, sympathomimetic agent and nasal decongestant.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
34
AdooQ Bioactive Compound Library
BiasDB
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Concise Guide to Pharmacology 2025/26
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
NCATS Inxight Approved Drugs
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
263
Molecular Weight
167.09
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
0.65
TPSA
52.49
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
alpha1
Target
Adrenergic Receptor
α1A-adrenergic receptor
α1B-adrenergic receptor
α1D-adrenergic receptor
¦Á1-adrenergic receptor
ADRA1A, ADRA1B, ADRA1D
Primary Target
Adrenergic ?1 Receptors
MOA
Agonist
alpha1A-Adrenoceptor Ligands
alpha1-Adrenoceptor Agonists
Adrenergic Receptor agonist
Member status
member
Indication
nasal congestion, hemorrhoids, hypotension
Disease Area
otolaryngology, gastroenterology, cardiology
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Therapeutic Class
Ophthalmologicals
Recommended Cell Concentration
100 nM
Source data
