General
Preferred name
naltrexone
Synonyms
Depade ()
Trexan ()
Naltrexone HCl ()
Antaxone ()
NALTREXONE HYDROCHLORIDE ()
Naltrexone hydrochloride dihydrate ()
ReVia ()
PTI-901 ()
Naltrexone (hydrochloride) ()
Naltrexone-d3 (CRM) ()
Naltrexona ()
Trexal ()
NSC-758439 ()
Vivitrol ()
Celupan ()
EN-1639A [As Hydrochloride] ()
EN-1639A FREE BASE ()
NALOREX ()
EN-1639A (AS HYDROCHLORIDE) ()
Naltrexone hydrochloride component of troxyca ()
OPIZONE ()
EN-1639A ()
Naltrexone hydrochloride component of embeda ()
ADEPEND ()
Naltrexone hydrochloride component of contrave ()
Naltrexone-d3 ()
NALTREXONE HYDROCHLORIDE COMPONENT OF CONTRAVE ()
NALTREXONE HYDROCHLORIDE COMPONENT OF EMBEDA ()
NALTREXONE HYDROCHLORIDE COMPONENT OF TROXYCA ()
P&D ID
PD010071
CAS
16676-29-2
16590-41-3
1261080-26-5
Tags
available
drug
Approved by
FDA
First approval
1984
Drug indication
gambling behaviour
Human immunodeficiency virus infection
Alcohol dependence
Pain
Drug Status
vet_approved
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION This is the active isomer of naltrexone. The (+) isomer is inactive at the opioid receptors. (GtoPdb)
PRICE 29
DESCRIPTION Potent melatonin agonist (Tocris Bioactive Compound Library)
DESCRIPTION Naltrexone is an opioid receptor antagonist. It is used in the treatment of alcohol dependence and in the prevention of relapse to opioid dependence. (Enamine Bioactive Compounds)
DESCRIPTION Naltrexone hydrochloride (Naltrexone HCl) is a synthetic opioid antagonist used in the prevention of relapse of opiate addiction and alcoholism. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
33
AdooQ Bioactive Compound Library
A11723
Axon Medchem Screening Library
2416
Cayman Chemical Bioactives
15520
18325
19323
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL19019
CHEMBL1201149
ChEMBL Drugs
CHEMBL19019
CHEMBL1201149
Concise Guide to Pharmacology 2017/18
1639
Concise Guide to Pharmacology 2019/20
1639
Concise Guide to Pharmacology 2021/22
1639
Concise Guide to Pharmacology 2023/24
1639
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00704
DrugBank Approved Drugs
DB00704
DrugCentral
1765
DrugCentral Approved Drugs
1765
DrugMAP
DMUL45H
DrugMAP Approved Drugs
DMUL45H
Enamine Bioactive Compounds
EBC-09166
Enamine BioReference Compounds
EUbOPEN Chemogenomics Library
EUB0000986
Guide to Pharmacology
1639
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL19019
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
5S6W795CQM
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
naltrexone-hcl
TargetMol Bioactive Compound Library
T0963
Tocris Bioactive Compound Library
0677
ZINC Tool Compounds
ZINC000000001773
External IDs
81
Properties
(calculated by RDKit )
Molecular Weight
341.16
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
6
Aromatic Ring Count
1
cLogP
1.53
TPSA
70.0
Fraction CSP3
0.65
Chiral centers
4.0
Largest ring
6.0
QED
0.85
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Opioid Receptor antagonist
Antagonist
Target
Opioid receptors
mu/kappa/delta
Opioid Receptor
OPRD1, OPRK1, OPRM1, SIGMAR1
Opioid antagonist
Primary Target
Miscellaneous Opioids
Indication
abstinence from alcohol
Biosynthetic Origin
Alkaloid
Therapeutic Indication
Antinarcotic
Therapeutic Class
CNS & PNS
Pathway
Endocrinology/Hormones
GPCR/G protein
Neuroscience
Recommended Cell Concentration
10 nM
Source data