General
Preferred name
DELAVIRDINE
Synonyms
DELAVIRDINE MESYLATE ()
U 90152 ()
BHAP-U 90152 ()
U 90152 (mesylate) ()
BHAP-U 90152 (mesylate) ()
Delavirdine (mesylate) ()
U 90152 mesylate ()
U-90152S ()
Delavirdine mesilate ()
U-90152T ()
Rescriptor ()
Delavirdine methanesulfonate ()
U-90152 ()
P&D ID
PD010070
CAS
147221-93-0
136817-59-9
Tags
natural product
drug
available
Approved by
FDA
First approval
1997
Drug Status
approved
Drug indication
Human immunodeficiency virus infection
Antiviral
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI), that is used to treat HIV-1 infections. (GtoPdb)
DESCRIPTION Selective reverse transcriptase inhibitor; antiretroviral (Tocris Bioactive Compound Library)
DESCRIPTION Non-nucleoside reverse transcriptase inhibitor (Tocriscreen Plus)
DESCRIPTION Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It is used as part of highly active antiretroviral therapy (HAART) for the treatment of human immunodeficiency virus (HIV) type 1. (BOC Sciences Bioactive Compounds)
Cell lines
3
Organisms
3
Compound Sets
24
AdooQ Bioactive Compound Library
A13274
Axon Medchem Screening Library
1815
BOC Sciences Bioactive Compounds
delavirdine-cas-136817-59-9-item-84-57976
Cayman Chemical Bioactives
24026
ChEMBL Approved Drugs
CHEMBL929
CHEMBL593
ChEMBL Drugs
CHEMBL929
CHEMBL593
Drug Repurposing Hub
DrugBank
DB00705
DrugBank Approved Drugs
DB00705
DrugCentral
799
DrugCentral Approved Drugs
799
DrugMAP
DM3NF5G
DrugMAP Approved Drugs
DM3NF5G
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS100932
Guide to Pharmacology
12674
MedChem Express Bioactive Compound Library
HY-10571A
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
delavirdine
TargetMol Bioactive Compound Library
T7212
Tocris Bioactive Compound Library
4149
Tocriscreen Plus
4149
External IDs
55
Properties
(calculated by RDKit )
Molecular Weight
456.19
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
2.72
TPSA
110.43
Fraction CSP3
0.36
Chiral centers
0.0
Largest ring
6.0
QED
0.53
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Target
Reverse Transcriptase
HIV
HIV-1
CYP3A4
NNRT inhibitor
Pathway
Anti-infection
Microbiology&virology
Proteases/Proteasome
Primary Target
RNA/DNA Polymerase
MOA
Inhibitor
non-nucleoside reverse transcriptase inhibitor
Indication
human immunodeficiency virus (HIV-1)
Therapeutic Class
Anti-HIV Agents
Solubility
In vitro:<br/>10 mM in DMSO
Source data