General
Preferred name
DIETHYLCARBAMAZINE
Synonyms
DIETHYLCARBAMAZINE CITRATE ()
Loxuran ()
Caritrol ()
Dicarocide ()
Diethylcarbamazine ()
Diethylcarbamazine (citrate) ()
Hetrazan ()
NSC-80513 ()
Difil ()
Ethylaminoazine citrate ()
Filarabits ()
Banocide ()
Decacide ()
Dirocide ()
Nemacide ()
Camin ()
P&D ID
PD010066
CAS
1642-54-2
16354-46-4
90-89-1
12672-34-3
Tags
natural product
drug
available
Approved by
FDA
First approval
1950
Drug Status
investigational
withdrawn
approved
vet_approved
Drug indication
Lymphatic filariasis
Anthelmintic
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Diethylcarbamazine is an anthelmintic drug that does not resemble other antiparasitic compounds. It is a synthetic organic compound which is highly specific for several parasites and does not contain any toxic metallic elements.
INDICATION Used for the treatment of certain filarial diseases, including tropical pulmonary eosinophilia, loiasis, and lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori.
Compound Sets
22
Axon Medchem Screening Library
3176
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL937
CHEMBL684
ChEMBL Drugs
CHEMBL937
CHEMBL684
Drug Repurposing Hub
DrugBank
DB00711
DrugBank Approved Drugs
DB00711
DrugCentral
873
DrugCentral Approved Drugs
873
DrugMAP
DM1TJ8F
DrugMAP Approved Drugs
DM1TJ8F
DrugMatrix
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
HY-12642
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
diethylcarbamazine-citrate
TargetMol Bioactive Compound Library
T1420
The Pathogen Box
The Spectrum Collection
Withdrawn 2.0
62
External IDs
53
Properties
(calculated by RDKit )
Molecular Weight
199.17
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
0
cLogP
0.7
TPSA
26.79
Fraction CSP3
0.9
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Disease
REFERENCE COMPOUNDS
MOA
Unknown molecular target
Lipoxygenase inhibitor
Target
Nematode GABA-A receptor
COX-1
ALOX5
ALOX5, PTGS1
Filaricidal drug
Parasite
Pathway
Immunology/Inflammation
Metabolism
Neuroscience
Anti-infection
Indication
filariasis
ATC
P02CB02
Therapeutic Class
Anthelmintics
Source data