General
Preferred name
DIETHYLCARBAMAZINE
Synonyms
DIETHYLCARBAMAZINE CITRATE ()
Caritrol ()
Loxuran ()
Dicarocide ()
Diethylcarbamazine ()
Diethylcarbamazine (citrate) ()
Difil ()
Hetrazan ()
Dirocide ()
Banocide ()
Ethylaminoazine citrate ()
NSC-80513 ()
Decacide ()
Dietilcarbamazina ()
Camin ()
P&D ID
PD010066
CAS
1642-54-2
16354-46-4
90-89-1
12672-34-3
Tags
available
drug
Approved by
FDA
First approval
1950
Drug indication
Lymphatic filariasis
infection
Drug Status
vet_approved
approved
withdrawn
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Diethylcarbamazine citrate is an orally active anthropoidal compound. Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism of filaria microfilaria. Diethylcarbamazine citrate has anti-inflammatory and antiparasitic activity[1][2][3].
PHARMACODYNAMICS
Diethylcarbamazine is an anthelmintic drug that does not resemble other antiparasitic compounds. It is a synthetic organic compound which is highly specific for several parasites and does not contain any toxic metallic elements.
INDICATION
Used for the treatment of certain filarial diseases, including tropical pulmonary eosinophilia, loiasis, and lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori.
DESCRIPTION
Diethylcarbamazine is a microfilaricidal agent used originally in onchocerciasis and lymphatic filiariasis study[1].
DESCRIPTION
Diethylcarbamazine citrate (Caritrol) is an anthelmintic used primarily as the citrate in the treatment of filariasis, particular infestations with Wucheria bancrofti or Loa loa. It is an inhibitor of arachidonic acid metabolism in filarial microfilaria.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Diethylcarbamazine is an anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa. The mechanism of action of diethylcarbamazine is thought to involve sensitizing the microfilariae to phagocytosis.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
24
Axon Medchem Screening Library
CeMM library of unique drugs (CLOUD)
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Pathogen Box
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
55
Molecular Weight
199.17
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
0
cLogP
0.7
TPSA
26.79
Fraction CSP3
0.9
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Disease
REFERENCE COMPOUNDS
MOA
Unknown molecular target
Lipoxygenase inhibitor
Target
Nematode GABA-A receptor
ALOX5
COX-1
Parasite
ALOX5, PTGS1
Filaricidal drug
Indication
filariasis
ATC
P02CB02
Pathway
Immunology/Inflammation
Metabolism
Microbiology/virology
Neuroscience
Anti-infection
Therapeutic Class
Anthelmintics
Source data
