General
Preferred name
apomorphine
Synonyms
(R)-(-)-Apomorphine hydrochloride ()
R(-) Apomorphine hydrochloride hemihydrate ()
Apomorphine SL ()
R-(???)-Apomorphine hydrochloride hemihydrate ()
Apomorphine hydrochloride hemihydrate ()
Apokyn ()
Kynmobi ()
Apomorphine hydrochloride hydrate ()
Apo-go pen ()
Apo-go ()
Uprima ()
Ixense ()
Apomorphinum muriaticum ()
Apomorph hcl ()
Kw-6500 ()
NSC-755875 ()
Apo-go pfs ()
Apomorphine hcl ()
Taluvian ()
Britaject ()
APOMORPHINE HYDROCHLORIDE ()
APL-130277 ()
VR-040 ()
6a.beta.-aporphine-10,11-diol ()
Apomorphinum ()
VR040 ()
(-)-Apomorphine (hydrochloride hydrate) ()
(-)-Apomorphine (hydrochloride) ()
P&D ID
PD010064
CAS
314-19-2
41372-20-7
58-00-4
58117-94-5
Tags
available
drug
obsolete probe
biased GPCR ligand
drug candidate
Approved by
FDA
First approval
2001
2004
Drug indication
Discovery agent
Parkinson disease
Idiopathic parkinson disease
Sexual dysfunction
Erectile dysfunction
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Apomorphine hydrochloride is a potent dopamine-receptor agonist. (GtoPdb)
DESCRIPTION Dopamine agonist; non-subtype-selective (Tocriscreen Total)
DESCRIPTION D1-like partial agonist (Tocris Bioactive Compound Library)
DESCRIPTION Apomorphine is a morphine derivative D2 dopamine agonist. It is indicated to treat hypomobility associated with Parkinson's. (Enamine Bioactive Compounds)
Cell lines
1
Organisms
3
Compound Sets
30
BiasDB
Apomorphine
Cayman Chemical Bioactives
34222
16094
ChEMBL Approved Drugs
CHEMBL3187985
CHEMBL53
ChEMBL Drugs
CHEMBL3187985
CHEMBL53
Concise Guide to Pharmacology 2017/18
33
Concise Guide to Pharmacology 2019/20
33
Concise Guide to Pharmacology 2021/22
33
Concise Guide to Pharmacology 2023/24
33
Concise Guide to Pharmacology 2025/26
33
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00714
DrugBank Approved Drugs
DB00714
DrugCentral
228
DrugCentral Approved Drugs
228
DrugMAP
DMPH7EO
DMX38HQ
DrugMAP Approved Drugs
DMX38HQ
Enamine Bioactive Compounds
EBC-26379
Guide to Pharmacology
33
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL53
NCATS Inxight Approved Drugs
N21FAR7B4S
NPC Screening Collection
Obsolete Compounds
apomorphine
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Tocris Bioactive Compound Library
2073
Tocriscreen Total
Withdrawn 2.0
EMA3
ZINC Tool Compounds
ZINC000000009073
External IDs
434
Properties
(calculated by RDKit )
Molecular Weight
267.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
2
cLogP
2.85
TPSA
43.7
Fraction CSP3
0.29
Chiral centers
1.0
Largest ring
6.0
QED
0.72
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Non-selective Dopamine
MOA
Agonist
Dopamine Receptor agonist
Target
ADRA2A, ADRA2B, ADRA2C, CALY, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A
Indication
Parkinson's Disease
ATC
G04BE07
N04BC07
Source data