General
Preferred name
paroxetine
Synonyms
PAROXETINE HYDROCHLORIDE ()
Paroxetine hydrochloride hemihydrate (MW = 374.83) ()
Paroxetine maleate ()
Paroxetine HCl ()
BRL29060 hydrochloride ()
FG-7051 ()
BRL29060A ()
Paroxetine (HCl) ()
Paxil ()
Seroxat ()
Paroxetine (hydrochloride) ()
BRL29060 ()
BRL29060 (hydrochloride) ()
BRL-29060A, FG-7051 ()
BRL-29060A mesylate,FG-7051 mesylate ()
Paroxetine hydrochloride hemihydrate ()
PAROXETINE MESYLATE ()
Arotin ()
Frosinor ()
BRL-29060 ()
Casbol ()
Arketis ()
Parogen ()
(-)3s,4r-paroxetine ()
Paxpar ()
Xetanor ()
Paroxetina ()
Motivan ()
Besitram ()
BRL 29060 ()
Daparox ()
Paroxetine ()
Brisdelle ()
Paroxetine methanesulphonate ()
Paroxetine mesilate ()
PO-T.MES ()
POT.MES ()
Paroxetine methanesulfonate ()
Mesafem ()
Pexeva ()
[3H]paroxetine ()
[3H]-Paroxetine ()
[3H]PAROXETINE ()
Paroxetine hydrochloride anhydrous ()
Paroxetine hydrochloride hydrate ()
Paxil Cr ()
NSC-758654 ()
Aropax ()
Deroxat ()
(-)-Paroxetine hydrochloride ()
AROPAX ()
DEROXAT ()
PAROXETINE HYDROCHLORIDE ANHYDROUS ()
PAROXETINE HYDROCHLORIDE HYDRATE ()
PAXIL CR ()
Paroxetine-d6 (hydrochloride) ()
Paroxetine (maleate) (CRM) ()
P&D ID
PD010063
CAS
78246-49-8
61869-08-7
64006-44-6
110429-35-1
217797-14-3
Tags
available
drug
nuisance
Approved by
FDA
First approval
2003
1992
Drug indication
Anxiety
panic disorder
Hot flashes
Depression
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Paroxetine hydrochloride is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an GRK2 inhibitor with IC50 of 14?¦ÌM. Paroxetine hydrochloride can be used for the research of depressive disorder[1][2][3].
DESCRIPTION Paroxetine is a selective serotonin-reuptake inhibitor (SSRI) antidepressant. An X-ray structure of crystals of paroxetine bound SERT, shows a single central binding site (see PDB entry 5I6X).. (GtoPdb)
DESCRIPTION Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches[1][2][3][4].
PRICE 29
PRICE 29
DESCRIPTION Selective serotonin reuptake inhibitor; antidepressant;Sold with permission of GlaxoSmithKline.;Actual molecular weight = 374.83 to account for 1/2 mole of water. (LOPAC library)
DESCRIPTION Paroxetine is a selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. (Enamine Bioactive Compounds)
DESCRIPTION Paroxetine hydrochloride (Paroxetine HCl) is a serotonin uptake inhibitor that is effective in the treatment of depression. (TargetMol Bioactive Compound Library)
DESCRIPTION Paroxetine is a inhibitor of serotonin uptake that is effective in the treatment of depression. (TargetMol Bioactive Compound Library)
DESCRIPTION Potent inhibitor of vesicular monoamine transport (Tocris Bioactive Compound Library)
DESCRIPTION Highly potent and selective 5-HT uptake inhibitor (Tocriscreen Total)
DESCRIPTION Paroxetine maleate is a highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki = 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. (BOC Sciences Bioactive Compounds)
DESCRIPTION Paroxetine hydrochloride hemihydrate is a antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). (BOC Sciences Bioactive Compounds)
DESCRIPTION Paroxetine hydrochloride hemihydrate (Paxil) is an effective and selective serotonin reuptake inhibitor (SSRI). (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
7
Compound Sets
35
AdooQ Bioactive Compound Library
A11904
BOC Sciences Bioactive Compounds
paroxetine-maleate-cas-64006-44-6-item-74178
paroxetine-hydrochloride-hemihydrate-cas-110429-35-1-54362
Cayman Chemical Bioactives
14998
40969
35603
ChEMBL Approved Drugs
CHEMBL490
CHEMBL1200609
CHEMBL6067650
ChEMBL Drugs
CHEMBL490
CHEMBL1200609
CHEMBL6067650
Concise Guide to Pharmacology 2017/18
4790
4561
Concise Guide to Pharmacology 2019/20
4790
4561
Concise Guide to Pharmacology 2021/22
4790
4561
Concise Guide to Pharmacology 2023/24
4790
4561
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00715
DrugBank Approved Drugs
DB00715
DrugCentral
2068
DrugCentral Approved Drugs
2068
DrugMAP
DM5PVQE
DrugMAP Approved Drugs
DM5PVQE
Enamine Bioactive Compounds
EBC-12122
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101651
EUbOPEN Chemogenomics Library
EUB0002089
Guide to Pharmacology
4790
4561
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL490
MedChem Express Bioactive Compound Library
HY-B0492
HY-122272
NCATS Inxight Approved Drugs
41VRH5220H
NIH Clinical Collections (NCC)
NPC Screening Collection
Nuisance compounds in cellular assays
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
paroxetine-hcl
paroxetine-mesylate
TargetMol Bioactive Compound Library
T1636
T8708
T1636L
The Spectrum Collection
Tocris Bioactive Compound Library
2141
Tocriscreen Total
External IDs
139
Properties
(calculated by RDKit )
Molecular Weight
329.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
2
cLogP
3.33
TPSA
39.72
Fraction CSP3
0.37
Chiral centers
2.0
Largest ring
6.0
QED
0.93
Structural alerts
1
CAD
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target
Adrenergic Receptor
Apoptosis
P2X Receptor
Serotonin Transporter
serotonin
serotonin reuptake
CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, HTR2A, SLC6A2, SLC6A4
G Protein-coupled Receptor Kinase (GRK)
5-HT
AChR
GRK2
Selectivity
Reuptake
Primary Target
5-HT Transporters
MOA
Inhibitor
selective serotonin reuptake inhibitor (SSRI)
Indication
depression, obsessive compulsive disorder (OCD), generalized anxiety disorder (GAD), panic disorders, posttraumatic stress disorder, social anxiety disorder
Pathway
Autophagy
GPCR/G protein
Neuroscience
Membrane Transporter/Ion Channel
Neuronal Signaling
Therapeutic Class
Antidepressants
Recommended Cell Concentration
None
Source data