General
Preferred name
NEDOCROMIL
Synonyms
FPL 59002 ()
Tilade ()
NEDOCROMIL SODIUM ()
nedocromil sodium, Allergan ()
NEDOCROMIL CALCIUM ()
Nedocromilo ()
FPL-59002 ()
Rapitil ()
FPL 59002KP ()
Nedocromil disodium salt ()
FPL-59002KP ()
Tilarin ()
Alocril ()
Tayled ()
FPL-59002KC ()
FPL 59002KC ()
Nedocromil (sodium salt) ()
P&D ID
PD010062
CAS
69049-73-6
69049-74-7
101626-68-0
Tags
available
drug
drug candidate
Approved by
FDA
First approval
1992
Drug Status
approved
investigational
Max Phase
4.0
Drug indication
Allergic conjunctivitis
eye allergy
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Nedocromil is considered to be a mast cell stabilising drug. Chemically it belongs to the benzopyrone family of compounds. In the US, production of inhaled nedocromil was terminated in 2008.
(GtoPdb)
DESCRIPTION
Nedocromil suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).
PRICE
80
DESCRIPTION
Nedocromil is an inhaled anti-inflammatory agent for the preventive management of asthma.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Nedocromil (FPL 59002) inhibits the action or formation of multiple mediators. Which including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
17
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMatrix
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
70
Molecular Weight
371.1
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
2.48
TPSA
126.81
Fraction CSP3
0.26
Chiral centers
0.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Neuronal Signaling
Indication
itching, conjunctivitis
Disease Area
neurology/psychiatry, ophthalmology
Target
CYSLTR1, CYSLTR2, FPR1, HSP90AA1, PTGDR
Histamine Receptor
Leukotriene Receptor
Prostaglandin Receptor
leukotriene C4 (LTC4)
prostaglandin D2 receptor
MOA
Histamine Receptor antagonist
Biosynthetic Origin
Other (Shikimate)
Therapeutic Indication
Nootropic
Therapeutic Class
CNS & PNS
Source data
