General
Preferred name
AZATADINE
Synonyms
AZATADINE MALEATE ()
SCH10649 ()
Azatadine 2-butenedioate (1:2) ()
Azatadine (dimaleate) ()
SCH10649,Azatadine Maleate ()
Azatadine dimaleate ()
SCH-10649 ()
Optimine ()
Azatadine maleate component of trinalin ()
Lergocil ()
NSC-759874 ()
SCH 10649 ()
Azatadina ()
Trinalin ()
Azatadine dimaleat ()
Azatadine (maleate) ()
P&D ID
PD010061
CAS
3978-86-7
3964-81-6
1445763-73-4
Tags
available
drug
Approved by
FDA
First approval
1977
Drug indication
Allergic rhinitis
allergic disease
Drug Status
approved
withdrawn
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Azatadine bimaleate is an inhibitor of histamine receptors and choline receptors with IC50s of 6.5 nM and 10 nM respectively.
PRICE
29
DESCRIPTION
Azatadine dimaleate (SCH10649) is an inhibitor for histamine??IC50=6.5 nM?? and cholinergic??IC50=10 nM??.
DESCRIPTION
Azatadine is a first-generation antihistamine and anticholinergic drug. Its marketing has been discontinued in many countries as its use has largely been repleaced by newer and more effective alternatives.
(GtoPdb)
DESCRIPTION
Azatadine is an H1 receptor antagonist used to treat perennial and allergic rhinitis as well as eustachian tube congestion.
(Enamine Bioactive Compounds)
DESCRIPTION
Azatadine dimaleate (SCH10649) is an inhibitor for histamine（IC50=6.5 nM） and cholinergic（IC50=10 nM）.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
24
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
53
Molecular Weight
290.18
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
2
cLogP
3.71
TPSA
16.13
Fraction CSP3
0.35
Chiral centers
0.0
Largest ring
7.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Histamine Receptor
Histamine H1 receptor
HRH1
Cholinergic
HT
Pathway
Immunology/Inflammation
GPCR/G protein
Neuronal Signaling
Neuroscience
MOA
Histamine Receptor antagonist
Indication
allergic rhinitis
ATC
R06AX09
Therapeutic Class
Antihistamines
Source data
