General
Preferred name
AZATADINE
Synonyms
AZATADINE MALEATE ()
Azatadine dimaleate ()
SCH10649 ()
Azatadine 2-butenedioate (1:2) ()
Azatadine (dimaleate) ()
SCH10649,Azatadine Maleate ()
NSC-759874 ()
Lergocil ()
Optimine ()
SCH 10649 ()
SCH-10649 ()
Trinalin ()
Azatadine (maleate) ()
P&D ID
PD010061
CAS
3978-86-7
3964-81-6
1445763-73-4
Tags
natural product
drug
available
Approved by
FDA
First approval
1977
Drug Status
approved
withdrawn
Drug indication
Allergic rhinitis
Antihistaminic
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Azatadine is a first-generation antihistamine and anticholinergic drug. Its marketing has been discontinued in many countries as its use has largely been repleaced by newer and more effective alternatives. (GtoPdb)
Compound Sets
22
Cayman Chemical Bioactives
29758
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL3544908
CHEMBL946
ChEMBL Drugs
CHEMBL3544908
CHEMBL946
Drug Repurposing Hub
DrugBank
DB00719
DrugBank Approved Drugs
DB00719
DrugCentral
268
DrugCentral Approved Drugs
268
DrugMAP
DMZ80SB
DrugMAP Approved Drugs
DMZ80SB
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
7119
MedChem Express Bioactive Compound Library
HY-B0170A
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
azatadine-dimaleate
TargetMol Bioactive Compound Library
T0236
Withdrawn 2.0
1230
External IDs
49
Properties
(calculated by RDKit )
Molecular Weight
290.18
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
2
cLogP
3.71
TPSA
16.13
Fraction CSP3
0.35
Chiral centers
0.0
Largest ring
7.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Histamine Receptor
Histamine H1 receptor
HT
Cholinergic
HRH1
Pathway
Immunology/Inflammation
GPCR/G protein
Neuronal Signaling
Neuroscience
MOA
Histamine Receptor antagonist
Indication
allergic rhinitis
ATC
R06AX09
Therapeutic Class
Antihistamines
Source data