General
Preferred name
CLODRONIC ACID
Synonyms
Clodronate disodium tetrahydrate ()
clodronic acid disodium tetrahydrate ()
CLODRONATE DISODIUM ()
Clastoban ()
Disodium clodronate tetrahydrate ()
Clodronate ()
Clodronate (disodium tetrahydrate) ()
Clodronic acid (disodium salt) ()
clodronate disodium, Abiogen ()
Disodium clodronate (tetrahydrate) ()
Clodronate (disodium salt) ()
ZK-00091106 ()
Bonefos ()
Disodium clodronate ()
Clodronic acid disodium salt anhydrous ()
Clodronic acid disodium salt ()
Clodronate disodium anhydrous ()
177501 ()
ZK 00091106 ()
Sodium clodronate hydrate ()
Clodronate (sodium salt hydrate) ()
P&D ID
PD010060
CAS
88416-50-6
22560-50-5
10596-23-3
Tags
available
drug candidate
drug
First approval
1986
Drug Status
investigational
approved
vet_approved
Drug indication
Regulator (calcium)
Hypercalcaemia
Max Phase
Phase 3
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Clodronic acid is a first generation (non-nitrogenous) bisphosphonate drug. Clinically used drugs can contain sodium clodronate tetrahydrate, sodium clodronate, disodium clodronate tetrahydrate or disodium clodronate.
Kato et al. (2017) report that clodronic acid-mediated inhibition of the vesicular nucleotide transporter (VNUT, SLC17A9) suggests that this drug has potential as a transporter-targeted (and notably, non-opioid) analgesic drug for the treatment of chronic neuropathic and inflammatory pain . In this study clodronic acid was selective for VNUT compared to other vesicular transporters tested. (GtoPdb)
Kato et al. (2017) report that clodronic acid-mediated inhibition of the vesicular nucleotide transporter (VNUT, SLC17A9) suggests that this drug has potential as a transporter-targeted (and notably, non-opioid) analgesic drug for the treatment of chronic neuropathic and inflammatory pain . In this study clodronic acid was selective for VNUT compared to other vesicular transporters tested. (GtoPdb)
DESCRIPTION
Matrix metalloproteinase 1 (MMP1) and collagenase inhibitor
(LOPAC library)
DESCRIPTION
Clodronic acid (INN) or clodronate disodium (USAN) is a first generation (non-nitrogenous) bisphosphonate. It is an anti-osteoporotic drug approved for the prevention and treatment of osteoporosis in post-menopausal women and men to reduce vertebral fractures, hyperparathyroidism, hypercalcemia in malignancy, multiple myeloma and fracture related pain because of its potent anti-inflammatory and analgesic effects shown as a reduction in inflammatory markers like IL-1β, IL-6, and TNF-alfa.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Clodronate binds to calcium and inhibits osteoclastic bone resorption and hydroxyapatite crystal formation and dissolution, resulting in a reduction of bone turnover. This agent may control malignancy-associated hypercalcemia, inhibit osteolytic bone metastasis and decrease pain.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
23
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
LOPAC library
NPC Screening Collection
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
73
Molecular Weight
243.89
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
4
Rotatable Bonds
2
Ring Count
0
Aromatic Ring Count
0
cLogP
0.43
TPSA
115.06
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
0.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
MMP1 / collagenase
Pathway
Apoptosis
Immunology/Inflammation
Target
IL-1??
IL-6
TNF-??
IL-1¦Â
TNF-¦Á
SLC25A4, SLC25A5, SLC25A6
MOA
IL receptor
TNF inhibitor
bone resorption inhibitor
Indication
osteoporosis, hyperparathyroidism, hypercalcemia, multiple myeloma
Disease Area
orthopedics, endocrinology, hematologic malignancy
Therapeutic Class
Antihypocalcemic Agents
Source data
