General
Preferred name
PROCAINE
Synonyms
PROCAINE HYDROCHLORIDE ()
Procaine HCl ()
Novocaine HCl ()
Novocaine ()
Vitamin H3 ()
Duracaine ()
Spinocaine ()
Procaine ()
Procaine (hydrochloride) ()
Procaini hydrochloridum ()
Jenacaine ()
Syntocain ()
Rocain ()
SP-01A ()
Neocaine ()
Sp01a ()
NSC-757280 ()
Novocain ()
Anestil ()
Omnicain ()
Enpro ()
Planocaine ()
Pasconeural N ()
Medaject ()
Naucaine ()
NSC-169497 ()
Procaine (hydrochloride) ()
P&D ID
PD010059
CAS
51-05-8
59-46-1
12663-50-2
Tags
natural product
drug
available
Approved by
FDA
First approval
1954
Drug Status
investigational
withdrawn
approved
vet_approved
Drug indication
Anaesthesia
Anesthetic (local)
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Procaine was approved by the FDA in combination with penicillin in 1948.
Marketed formulations may contain procaine hydrochloride (PubChem CID 5795). In the WHO Essential Medicines list as procaine benzylpenicillin. (GtoPdb)
DESCRIPTION Na+ channel blocker (LOPAC library)
DESCRIPTION Procaine is a local anesthetic drug of the amino ester group, which acts through multiple targets. (BOC Sciences Bioactive Compounds)
Compound Sets
28
BOC Sciences Bioactive Compounds
procaine-cas-59-46-1-item-84-72569
Cayman Chemical Bioactives
20093
ChEMBL Approved Drugs
CHEMBL1200841
CHEMBL569
ChEMBL Drugs
CHEMBL1200841
CHEMBL569
Concise Guide to Pharmacology 2017/18
4291
Concise Guide to Pharmacology 2019/20
4291
Concise Guide to Pharmacology 2021/22
4291
Concise Guide to Pharmacology 2023/24
4291
Drug Repurposing Hub
DrugBank
DB00721
DrugBank Approved Drugs
DB00721
DrugCentral
2271
DrugCentral Approved Drugs
2271
DrugMAP
DM4LSNE
DrugMAP Approved Drugs
DM4LSNE
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
4291
JUMP-Target 1 Compound Set
4914
LOPAC library
MedChem Express Bioactive Compound Library
HY-B0546A
HY-B0546
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
procaine-novocaine-hcl
TargetMol Bioactive Compound Library
T0802
T0029
Withdrawn 2.0
122
External IDs
71
Properties
(calculated by RDKit )
Molecular Weight
236.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
1
Aromatic Ring Count
1
cLogP
1.77
TPSA
55.56
Fraction CSP3
0.46
Chiral centers
0.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
GABA Receptor
5-HT3
nAChR
NMDA Receptor
Sodium Channel
CHRNA2, GRIN3A, HTR3A, KCNMA1, KCNMB1, KCNMB2, KCNMB3, KCNMB4, KCNN1, KCNN2, KCNN3, KCNN4, MAOA, MAOB, RYR1, RYR2, SCN10A, SLC6A3
HTR3A
Bacterial
DNA/RNA Synthesis
Histone Demethylase
AChR,NMDAR,Sodium Channel
Pathway
Neuronal Signaling
GPCR/G protein
Membrane Transporter/Ion Channel
Neuroscience
Anti-infection
Cell Cycle/DNA Damage
Epigenetics
Indication
anesthetic
MOA
HMGCR inhibitor
ATC
C05AD05
N01BA02
N01BA52
S01HA05
Therapeutic Class
Anesthetics
Source data