General
Preferred name
PROCAINE
Synonyms
PROCAINE HYDROCHLORIDE ()
Procaine ()
Procaine (hydrochloride) ()
Novocaine HCl ()
Gerovital H3 ()
Procaine HCl ()
Procaine (hydrochloride) ()
Jenacaine ()
Procaine hydrochloride component of cardioplegin ()
NSC-757280 ()
Naucaine ()
Procaini hydrochloridum ()
Gero ()
Neocaine ()
Medaject ()
Pasconeural N ()
Enpro ()
Omnicain ()
SP-01A ()
Sp01a ()
Novocain ()
Rocain ()
Syntocain ()
Anestil ()
Procaine hydrochloride component of achromycin ()
Planocaine ()
Solution of novocain ()
Procaina ()
NSC-169497 ()
P&D ID
PD010059
CAS
51-05-8
59-46-1
12663-50-2
Tags
available
drug
Approved by
FDA
First approval
1954
Drug indication
osteomyelitis
HIV infection
Anaesthesia
Drug Status
vet_approved
approved
withdrawn
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Procaine hydrochloride (Novocaine HCl) is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodiumchannels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.
DESCRIPTION
Procaine was approved by the FDA in combination with penicillin in 1948.
Marketed formulations may contain procaine hydrochloride (PubChem CID 5795). In the WHO Essential Medicines list as procaine benzylpenicillin. (GtoPdb)
Marketed formulations may contain procaine hydrochloride (PubChem CID 5795). In the WHO Essential Medicines list as procaine benzylpenicillin. (GtoPdb)
PRICE
29
DESCRIPTION
Procaine (Vitamin H3) is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block.
DESCRIPTION
Na+ channel blocker
(LOPAC library)
DESCRIPTION
Procaine hydrochloride is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. Procaine acts by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. It also inhibits muscarinic acetylcholine receptor family and cholinergic receptor.
(Enamine Bioactive Compounds)
DESCRIPTION
Procaine is a local anesthetic drug of the amino ester group, which acts through multiple targets.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
29
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
JUMP-Target 1 Compound Set
LOPAC library
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
76
Molecular Weight
236.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
1
Aromatic Ring Count
1
cLogP
1.77
TPSA
55.56
Fraction CSP3
0.46
Chiral centers
0.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
GABA Receptor
CHRNA2, GRIN3A, HTR3A, KCNMA1, KCNMB1, KCNMB2, KCNMB3, KCNMB4, KCNN1, KCNN2, KCNN3, KCNN4, MAOA, MAOB, RYR1, RYR2, SCN10A, SLC6A3
HTR3A
Bacterial
DNA/RNA Synthesis
Histone Demethylase
AChR,NMDAR,Sodium Channel
Pathway
Neuronal Signaling
Anti-infection
Cell Cycle/DNA Damage
Epigenetics
Indication
anesthetic
MOA
HMGCR inhibitor
ATC
C05AD05
N01BA02
N01BA52
S01HA05
Therapeutic Class
Anesthetics
Source data
