General
Preferred name
METHOXAMINE
Synonyms
METHOXAMINE HYDROCHLORIDE ()
Metoxamina ()
Methoxamine HCl ()
methoxamine gel, Norgine ()
Vasoxine HCl ()
Vasoxine ()
Vasoxyl ()
NSC-757102 ()
Nrl001 ()
NRL-001 ()
P&D ID
PD010058
CAS
61-16-5
390-28-3
Tags
drug
natural product
biased GPCR ligand
available
Approved by
FDA
Drug Status
investigational
approved
Drug indication
Hypertension
Max Phase
Phase 4
First approval
1982
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Methoxamine is an brain-penetrant α1-adrenoceptor agonist.
(GtoPdb)
DESCRIPTION
Methoxamine Hydrochloride is an alpha-1 adrenergic agonist, similar in structure to butaxamine and 2,5-DMA. It causes prolonged peripheral vasoconstriction. It induces vasoconstriction of skin and splanchnic blood vessels, thus increasing peripheral vascular resistance and raising mean arterial blood pressure. lt is used for the treatment of paroxysmal supraventricular tachycardia and is used as a booster in the state of low blood pressure. It has been listed.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
alpha1 Adrenoceptor agonist
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
26
BiasDB
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
Ki Database
LOPAC library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
47
Molecular Weight
211.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
1
cLogP
1.08
TPSA
64.71
Fraction CSP3
0.45
Chiral centers
2.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
alpha1
Pathway
Neuroscience
GPCR/G protein
Target
Adrenergic Receptor
ADRA1A, ADRA1B, ADRA1D
MOA
Adrenergic Receptor antagonist
Adrenergic Receptor agonist
Indication
hypotension
Therapeutic Class
Antihypertensive Agents
Solubility
Soluble in DMSO, not in water
Source data
