General
Preferred name
METHOXAMINE
Synonyms
METHOXAMINE HYDROCHLORIDE ()
Metoxamina ()
Methoxamine HCl ()
methoxamine gel, Norgine ()
Vasoxine HCl ()
Vasoxine ()
NSC-757102 ()
Vasoxyl ()
Nrl001 ()
NRL-001 ()
P&D ID
PD010058
CAS
61-16-5
390-28-3
Tags
available
drug
biased GPCR ligand
Approved by
FDA
Drug indication
Hypertension
Fecal incontinence
Cardiovascular disease
Drug Status
approved
investigational
Max Phase
4.0
First approval
1982
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Methoxamine is an brain-penetrant α1-adrenoceptor agonist.
(GtoPdb)
DESCRIPTION
Methoxamine Hydrochloride is an alpha-1 adrenergic agonist, similar in structure to butaxamine and 2,5-DMA. It causes prolonged peripheral vasoconstriction. It induces vasoconstriction of skin and splanchnic blood vessels, thus increasing peripheral vascular resistance and raising mean arterial blood pressure. lt is used for the treatment of paroxysmal supraventricular tachycardia and is used as a booster in the state of low blood pressure. It has been listed.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
alpha1 Adrenoceptor agonist
(LOPAC library)
DESCRIPTION
Methoxamine hydrochloride is an alpha-adrenergic agonist that causes prolonged peripheral vasoconstriction. It is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure. It is indicated for the treatment and management of hypotension.
(Enamine Bioactive Compounds)
DESCRIPTION
Methoxamine hydrochloride (Methoxamine HCl) is an alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
27
BiasDB
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
Ki Database
LOPAC library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
48
Molecular Weight
211.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
1
cLogP
1.08
TPSA
64.71
Fraction CSP3
0.45
Chiral centers
2.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
alpha1
Target
Adrenergic Receptor
ADRA1A, ADRA1B, ADRA1D
MOA
Adrenergic Receptor antagonist
Adrenergic Receptor agonist
Indication
hypotension
Pathway
GPCR/G protein
Neuroscience
Therapeutic Class
Antihypertensive Agents
Solubility
Soluble in DMSO, not in water
Source data
