General
Preferred name
TRIMIPRAMINE
Synonyms
TRIMIPRAMINE MALEATE ()
Surmontil maleate ()
Trimipramine (maleate) ()
Trimipramine maleate salt ()
NSC-758386 ()
Stangyl ()
Surmontil ()
Trimipramina ()
IL 6001 ()
7162 RP ()
IL-6001 ()
Trimeproprimine ()
7162-RP ()
Trimipramine-d3 (maleate) ()
P&D ID
PD010056
CAS
521-78-8
739-71-9
3564-75-8
3564-66-7
Tags
available
drug
nuisance
Approved by
FDA
First approval
1979
Drug indication
Anxiety
Major depressive disorder
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Trimipramine maleate is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively[1]. Trimipramine maleate is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC50 values of 4.99 ¦ÌM, 2.11 ¦ÌM, 3.72 ¦ÌM, 8.00 ¦ÌM, respectively[2]. Trimipramine maleate has vascular activity and anxiolytic efficacy[3].
DESCRIPTION
Trimipramine is a tricyclic antidepressant (TCA) with antidepressant, anxiolytic, antipsychotic and sedative effects. Trimipramine is a racemic compound of two enantiomers; (S)-trimipramine and (R)-trimipramine. We show the non-stereo structure to represent the mixture.
Marketed formulations may contain trimipramine maleate (PubChem CID 5282318). (GtoPdb)
Marketed formulations may contain trimipramine maleate (PubChem CID 5282318). (GtoPdb)
DESCRIPTION
Serotonin reuptake inhibitor that also blocks norepinephrine reuptake; antidepressant
(LOPAC library)
DESCRIPTION
Trimipramine Maleate is a tricyclic antidepressant for the treatment of depression and depression accompanied by anxiety.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Trimipramine maleate (Surmontil maleate) appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. Trimipramine Maleate is the maleate salt form of trimipramine, a tricyclic secondary amine of the dibenzazepine class, with an antidepressant property.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Trimipramine is a tricyclic antidepressant. It is serotonin and norepinephrine transport inhibitor with antipsychotic and sedative properties.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
23
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
Ki Database
LOPAC library
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
Nuisance compounds in cellular assays
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
73
Molecular Weight
294.21
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
4.12
TPSA
6.48
Fraction CSP3
0.4
Chiral centers
1.0
Largest ring
7.0
QED
0.84
Structural alerts
1
CAD
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Reuptake
Pathway
GPCR/G protein
Immunology/Inflammation
Microbiology/virology
Neuroscience
Anti-infection
Neuronal Signaling
Target
5-HT Receptor
Bacterial
5-HT
Adrenergic Receptor
DA transporter
dopamine
H1 receptor
Noradrenaline transporter (Sodium-dependent)
Sert (Sodium-dependent)
Therapeutic Class
Antidepressants
Solubility
Soluble in DMSO
Soluble in Chloroform (Slightly), Methanol (Slightly)
Source data
