General
Preferred name
ROCURONIUM
Synonyms
Org-9426 ()
ORG 9426 (Bromide) ()
ORG 9426 ()
ROCURONIUM BROMIDE ()
ORG 9426 (Bromide)ORG 9426 ()
Rocuronium (Bromide) ()
Bromuro de rocuronio ()
Esmeron ()
Zemuron ()
Bromure de rocuronium ()
Rocuronium ion ()
Rocuronium cation ()
P&D ID
PD010055
CAS
119302-91-9
143558-00-3
Tags
available
drug
Approved by
FDA
First approval
1994
Drug indication
Neuromuscular Blocking Agent
Muscle spasm
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Approved as rocuronium bromide.
The neuromuscular blockade induced by rocuronium can be reversed by administering the selective relaxant binding agent (SRBA) sugammadex (PubChem CID 6918584, a.k.a. Bridion®, Org 25969). (GtoPdb)
The neuromuscular blockade induced by rocuronium can be reversed by administering the selective relaxant binding agent (SRBA) sugammadex (PubChem CID 6918584, a.k.a. Bridion®, Org 25969). (GtoPdb)
DESCRIPTION
Rocuronium is an aminosteroid non-depolarizing neuromuscular blocker and a muscle relaxant used for modern anaesthesia during endotracheal intubation.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
21
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
58
Molecular Weight
529.4
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
6
Aromatic Ring Count
0
cLogP
4.41
TPSA
59.0
Fraction CSP3
0.91
Chiral centers
10.0
Largest ring
6.0
QED
0.32
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Neuroscience
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
mAChR
CHRM2, CHRNA2, HTR3A
nAChR
MOA
AChR
acetylcholine receptor antagonist
Indication
anesthetic
Therapeutic Class
Neuromuscular Nondepolarizing Agents
Source data
