General
Preferred name
PRALIDOXIME
Synonyms
PRALIDOXIME CHLORIDE ()
PRALIDOXIME MESYLATE ()
Pralidoxime ()
2-PAM chloride ()
2-Pyridinealdoxime methochloride ()
2-PAM (chloride) ()
Pralidoxime (chloride) ()
Pralidoxime (iodide) ()
2-PAM ()
PRALIDOXIME IODIDE ()
Pralidoxime chloride (autoinjector) ()
Pralidoxime chloride component of duodote ()
Protopam Chloride ()
Contrathion ()
NSC-164614 ()
Pralidoxime chloride component of atnaa ()
Protopam ()
Pralidoxime methane sulphonate ()
Pralidoxime mesilate ()
Pralidoxime methanesulfonate ()
Pralidoxime ion ()
Pralidoxime cation ()
Atnaa ()
Pralidoxime ()
Ioduro de pralidoxima ()
Iodure de pralidoxime ()
Pam ()
NSC-7760 ()
NSC-40164 ()
P&D ID
PD010052
CAS
154-97-2
6735-59-7
94-63-3
51-15-0
Tags
available
drug
drug candidate
Approved by
FDA
First approval
1964
Drug indication
poisoning
Myasthenia gravis
Poisoning due to pesticides and chemicals
Drug Status
vet_approved
approved
investigational
Max Phase
2.0
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning[1][2].
PRICE 29
DESCRIPTION Usually available as the chloride or methiodide salts. (GtoPdb)
DESCRIPTION Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning[1][2].
DESCRIPTION Pralidoxime HCl is an antidote to organophosphate pesticides and chemicals. It is an acetylcholinesterase (AChE) reactivator. (Enamine Bioactive Compounds)
DESCRIPTION Pralidoxime Chloride (2-PAM chloride) is a useful agent in the treatment of organophosphate poisoning. Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by organophosphates or acetylcholinesterase inhibitors (nerve agents). (TargetMol Bioactive Compound Library)
Compound Sets
26
Cayman Chemical Bioactives
23666
ChEMBL Approved Drugs
CHEMBL748
CHEMBL1420
ChEMBL Drugs
CHEMBL748
CHEMBL2104739
CHEMBL1420
CHEMBL14577
Concise Guide to Pharmacology 2017/18
4652
Concise Guide to Pharmacology 2019/20
4652
Concise Guide to Pharmacology 2021/22
4652
Concise Guide to Pharmacology 2023/24
4652
Drug Repurposing Hub
DrugBank
DB00733
DrugBank Approved Drugs
DB00733
DrugCentral
2231
DrugCentral Approved Drugs
2231
DrugMAP
DMGQ0ZI
DrugMAP Approved Drugs
DMGQ0ZI
DrugMatrix
Enamine Bioactive Compounds
EBC-09105
Enamine BioReference Compounds
Guide to Pharmacology
4652
7597
MedChem Express Bioactive Compound Library
HY-B1200
HY-B1738A
NCATS Inxight Approved Drugs
P7MU9UTP52
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
pralidoxime-chloride
pralidoxime-lodide
TargetMol Bioactive Compound Library
T1111
The Spectrum Collection
External IDs
121
Properties
(calculated by RDKit )
Molecular Weight
137.07
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
0.32
TPSA
36.47
Fraction CSP3
0.14
Chiral centers
0.0
Largest ring
6.0
QED
0.26
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
AChE
ACHE, BCHE
Cholinesterase (ChE)
AChR
MOA
AChR antagonist
Acetylcholinesterase inhibitor
Indication
organophosphate poisoning
Pathway
Neuroscience
Neuronal Signaling
Source data