General
Preferred name
PENTAMIDINE
Synonyms
PENTAMIDINE ISETHIONATE ()
Mb 800 ()
Pentamidine (dihydrochloride) ()
MP601205 dihydrochloride ()
PENTAMIDINE DIISETHIONATE ()
Pentamidine isethionate salt ()
MP-601205 dihydrochloride ()
MP-601205 (dihydrochloride) ()
Pentamidine ()
pentamidine isethionate, Oncozyme ()
Pentamidine (isethionate) ()
MP-601205 (isethionate) ()
MP-601205 ()
Pentamidine dihydrochloride ()
Pentam ()
OCZ103-OS ()
NSC-757400 ()
MB 800 ()
Pentamidine diisetionate ()
RP 2512 ()
Pentacarinat ()
Pentamidine Isetionate ()
Pentamidini isetionas ()
NSC-620107 ()
Nebupent ()
Pentamidine diisethionate ()
Pentamidine Isethionate ()
RP-2512 FREE BASE ()
NSC-9921 ()
RP-2512 ()
MB-800 FREE BASE ()
GNF-Pf-3680 ()
RP 2512 FREE BASE ()
Pentam 300 ()
MB-800 (AS ISETHIONATE) ()
Pentamidina ()
MB-800 ()
MB 800 FREE BASE ()
P&D ID
PD010048
CAS
100-33-4
50357-45-4
140-64-7
Tags
available
drug
Approved by
FDA
First approval
1984
Drug indication
Trypanosomiasis
Human immunodeficiency virus infection
infection
Fungal infection
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Pentamidine isethionate (MP-601205 isethionate) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine isethionate inhibits parasite Leishmania infantum with an IC50 of 2.5 ¦ÌM. Pentamidine isethionate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine isethionate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].
PRICE
44
PRICE
66
DESCRIPTION
Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent effective against various microorganisms, including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi (Pneumocystis jirovecii). It is a potent and selective inhibitor of protein tyrosine phosphatases and phosphatase of regenerating liver. Pentamidine dihydrochloride inhibits the parasite Leishmania infantum with an IC50 of 2.5 ??M.
DESCRIPTION
Pentamidine isethionate (Pentamidine diisethionate) is a synthetic amidine derivative, Pentamidine Isethionate is an antiprotozoal and antifungal agent.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Pentamidine is an antiprotozoal agent.Pentamidine is a potent and selective protein tyrosine phosphatases and phosphatase of regenerating liver inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment.
(Enamine Bioactive Compounds)
DESCRIPTION
Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein. It is an antimicrobial medication given for prevention and treatment of Pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii (formerly known as Pneumocystis carinii), a severe interstitial type of pneumonia often seen in patients with HIV infection. The drug is also the mainstay of treatment for stage I infection with Trypanosoma brucei gambiense (West African Trypanosomiasis).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent effective against various microorganisms, including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi (Pneumocystis jirovecii). It is a potent and selective inhibitor of protein tyrosine phosphatases and phosphatase of regenerating liver. Pentamidine dihydrochloride inhibits the parasite Leishmania infantum with an IC50 of 2.5 μM.
(TargetMol Bioactive Compound Library)
DESCRIPTION
NMDA glutamate receptor antagonist; neuroprotective agent; antimicrobial agent prescribed for the treatment of AIDS-associated Pneumocystis carinii pneumonia
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
14
Organisms
26
Compound Sets
29
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
NCATS Inxight Approved Drugs
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
The Pathogen Box
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
82
Molecular Weight
340.19
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
10
Ring Count
2
Aromatic Ring Count
2
cLogP
2.88
TPSA
118.2
Fraction CSP3
0.26
Chiral centers
0.0
Largest ring
6.0
QED
0.3
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
NMDA
Disease
REFERENCE COMPOUNDS
Pathway
Anti-infection
Metabolism
Microbiology/virology
Metabolic Enzyme/Protease
MOA
Unknown molecular target
Antibacterial
anti-pneumocystis agent
Target
DNA
Kinetoplast DNA
TRDMT1
antibiotic
Bacterial
Fungal
Parasite
phosphatase
Antifungal
Indication
pneumonia
Therapeutic Class
Antifungal Agents
Source data
