General
Preferred name
CERULETIDE
Synonyms
Ceruletide ()
CERULETIDE DIETHYLAMINE ()
Caerulein ()
Cerulein ()
FI-6934 ()
Caerulein (FI-6934) ()
Ceruletide, Cerulein ()
Ceosunin ()
Tymtran ()
Ceruletide diethylamine salt ()
Caerulein diethylamine ()
Takus ()
Caerulein (acetate) ()
P&D ID
PD010046
CAS
17650-98-5
2760881-68-1
Tags
natural product
drug
available
Approved by
FDA
Drug Status
approved
withdrawn
Drug indication
Caerulein stimulated gastric and pancreatic secretion
Stimulant (gastric secretory)
Solid tumour/cancer
Max Phase
Phase 4
First approval
1982
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS
Caerulein is a specific decapeptide similar in action and composition to the natural gastrointestinal peptide hormone cholecystokinin that stimulates gastric, biliary, and pancreatic secretion. It also exerts stimulatory actions on certain smooth muscles.
INDICATION
Caerulein is used in the treatment of paralytic ileus and as diagnostic aid in pancreatic malfunction.
DESCRIPTION
Ceruletide is a decapeptide derivative of cholecystokinin with the amino acid sequence is Pglu-Gln-Asp-Tyr[SO3H]-Thr-Gly-Trp-Met-Asp-Phe-NH2 and originally isolated from the skin of the Australian green tree frog, Litoria caerulea. In the research setting ceruletide can be used to induce pancreatitis in experimental animal models.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
14
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
37
Molecular Weight
1351.45
Hydrogen Bond Acceptors
19
Hydrogen Bond Donors
17
Rotatable Bonds
38
Ring Count
5
Aromatic Ring Count
4
cLogP
-4.52
TPSA
551.4
Fraction CSP3
0.41
Chiral centers
10.0
Largest ring
6.0
QED
0.02
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CCKAR
Cholecystokinin Receptor
CCK Receptor
MOA
CCK receptor agonist
ATC
V04CC04
Therapeutic Class
Diagnostic Agents
Pathway
GPCR/G protein
Neuronal Signaling
Source data
