General
Preferred name
dexbrompheniramine
Synonyms
(+)-Brompheniramine maleate ()
(+)-Brompheniramine ()
(S)-Brompheniramine ()
DEXBROMPHENIRAMINE MALEATE ()
Brompheniramine, (s)- ()
Brompheniramine d-form ()
Dexbromfeniramina ()
Dexbrompheniramine maleate component of disobrom ()
Brompheniramine d-form maleate ()
Dexbrompheniramine maleate component of disophrol ()
Disomer ()
Dexbrompheniramine maleate component of brompheril ()
Dexbrompheniramine maleate component of drixoral plus ()
Dexbrompheniramine maleate component of resporal ()
Dexbrompheniramine maleate component of drixoral ()
P&D ID
PD010045
CAS
132-21-8
2391-03-9
Tags
available
drug
Approved by
FDA
First approval
1963
Drug indication
Seasonal allergic rhinitis
Hay fever
allergic disease
Drug Status
approved
withdrawn
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Chemically, dexbrompheniramine is the pharmacologically active dextrorotatory isomer of . (GtoPdb)
DESCRIPTION Dexbrompheniramine is an orally active H1 receptor antagonist. Dexbrompheniramine is an antihistamine that reduces the effects of natural chemical histamine. Dexbrompheniramine can be used for the research of hay fever and urticaria[1].
DESCRIPTION Dexbrompheniramine is an histamine H1-receptor antagonist used for the treatment of allergic conditions including hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of brompheniramine. Dexbrompheniramine is a first generation antihistamine that reduces the effects of natural chemical histamine in the body including the symptoms like sneezing, itching, watery eyes, and runny nose. (BOC Sciences Bioactive Compounds)
DESCRIPTION H1 Histamine receptor antagonist (LOPAC library)
Compound Sets
15
BOC Sciences Bioactive Compounds
dexbrompheniramine-cas-132-21-8-item-57274
ChEMBL Approved Drugs
CHEMBL1201287
CHEMBL1200638
ChEMBL Drugs
CHEMBL1201287
CHEMBL1200638
Drug Repurposing Hub
DrugBank
DB00405
DrugBank Approved Drugs
DB00405
DrugCentral
830
DrugCentral Approved Drugs
830
DrugMAP
DMKVWGE
DrugMAP Approved Drugs
DMKVWGE
Guide to Pharmacology
7588
LOPAC library
MedChem Express Bioactive Compound Library
HY-A0191
NCATS Inxight Approved Drugs
75T64B71RP
NIH Clinical Collections (NCC)
External IDs
41
Properties
(calculated by RDKit )
Molecular Weight
318.07
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
3.93
TPSA
16.13
Fraction CSP3
0.31
Chiral centers
1.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
H1
Disease Area
allergy, otolaryngology
Indication
allergic rhinitis, common cold
Target
HRH1
Endogenous Metabolite
Histamine Receptor
MOA
Histamine Receptor antagonist
Therapeutic Class
Antihistamines
Pathway
GPCR/G protein
Immunology/Inflammation
Metabolic Enzyme/Protease
Neuronal Signaling
Solubility
Soluble in DMSO
Source data