General
Preferred name
dexbrompheniramine
Synonyms
(+)-Brompheniramine maleate ()
DEXBROMPHENIRAMINE MALEATE ()
Brompheniramine, (s)- ()
Brompheniramine d-form ()
Dexbrompheniramine fumarate ()
Disomer ()
Brompheniramine d-form maleate ()
P&D ID
PD010045
CAS
132-21-8
2391-03-9
Tags
natural product
drug
available
Approved by
FDA
First approval
1963
Drug Status
approved
withdrawn
Drug indication
Hay fever
Antihistaminic
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Chemically, dexbrompheniramine is the pharmacologically active dextrorotatory isomer of .
(GtoPdb)
DESCRIPTION
H1 Histamine receptor antagonist
(LOPAC library)
DESCRIPTION
Dexbrompheniramine is an histamine H1-receptor antagonist used for the treatment of allergic conditions including hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of brompheniramine. Dexbrompheniramine is a first generation antihistamine that reduces the effects of natural chemical histamine in the body including the symptoms like sneezing, itching, watery eyes, and runny nose.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
14
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
LOPAC library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
39
Molecular Weight
318.07
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
3.93
TPSA
16.13
Fraction CSP3
0.31
Chiral centers
1.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
H1
Disease Area
allergy, otolaryngology
Indication
allergic rhinitis, common cold
Target
HRH1
MOA
Histamine Receptor antagonist
Therapeutic Class
Antihistamines
Solubility
Soluble in DMSO
Source data
