General
Preferred name
miglustat
Synonyms
N-Butyldeoxynojirimycin, Hydrochloride ()
NB-DNJ hydrochloride ()
OGT918 hydrochloride ()
N-Butyldeoxynojirimycin ()
NB-DNJ ()
OGT918 ()
Miglustat hydrochloride ()
Miglustat HCl ()
Zavesca ()
Miglustat (hydrochloride) ()
OGT 918 ()
N-Butyldeoxynojirimycin (hydrochloride) ()
NB-DNJ (hydrochloride) ()
OGT 918 (hydrochloride) ()
Zavesca, N©\butyldeoxynojirimycin, OGT 918 ()
Butyldeoxynojirimycin ()
OGT-918 ()
N-Butyldeoxynojirimycin (hydrochloride) ()
N-Butyldeoxynojirimycin-d9 (hydrochloride) ()
P&D ID
PD010037
CAS
72599-27-0
210110-90-0
134282-77-2
1883545-57-0
Tags
prodrug
natural product
drug
available
Approved by
EMA
FDA
First approval
2003
2002
Drug Status
approved
Drug indication
Type 1 gaucher disease
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Marketed formulations may contain miglustat hydrochloride (PubChem CID 71299591). (GtoPdb)
DESCRIPTION Antianginal, activates pyruvate dehydrogenase (Tocris Bioactive Compound Library)
Cell lines
1
Organisms
3
Compound Sets
31
AdooQ Bioactive Compound Library
A12797
Cayman Chemical Bioactives
21065
34852
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1029
ChEMBL Drugs
CHEMBL1029
Concise Guide to Pharmacology 2017/18
4841
Concise Guide to Pharmacology 2019/20
4841
Concise Guide to Pharmacology 2021/22
4841
Concise Guide to Pharmacology 2023/24
4841
Drug Repurposing Hub
DrugBank
DB00419
DrugBank Approved Drugs
DB00419
DrugCentral
1807
DrugCentral Approved Drugs
1807
DrugMAP
DM5J64S
DrugMAP Approved Drugs
DM5J64S
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100764
Guide to Pharmacology
4841
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1029
MedChem Express Bioactive Compound Library
HY-17020A
HY-17020
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
ADN3S497AZ
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Pandemic Response Box
ReFrame library
Selleckchem Bioactive Compound Library
miglustat
TargetMol Bioactive Compound Library
T12039
Tocris Bioactive Compound Library
3117
ZINC Tool Compounds
ZINC000003794711
External IDs
63
Properties
(calculated by RDKit )
Molecular Weight
219.15
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
4
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
0
cLogP
-1.45
TPSA
84.16
Fraction CSP3
1.0
Chiral centers
4.0
Largest ring
6.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
ceramide glucosyltransferase inhibitor
Inhibitor
SGLT-3 Activators
Pharmacological Chaperones
alpha-Glucosidase Inhibitors
Ceramide Glucosyltransferase Inhibitors
glycosyl transferase inhibitor
Target
Ceramide glucosyltransferase
UGCG
Glucosylceramide Synthase (GCS)
Transferase
Primary Target
Glycosylases
Member status
member
Indication
Gaucher disease
Biosynthetic Origin
Carbohydrate
Therapeutic Indication
Gaucher's Disease
Therapeutic Class
Metabolic Disorders
Anti-HIV Agents
Pathway
Neuronal Signaling
Source data