General
Preferred name
PROMAZINE
Synonyms
PROMAZINE HYDROCHLORIDE ()
Sinophenin ()
Romtiazin hydrochloride ()
Sinophenin hydrochloride ()
Promazine (HCl) ()
Romtiazin hydrochloride, Sinophenin hydrochloride ()
Prazine ()
Promazine hcl ()
Protactyl ()
Sparine ()
Tranquazine ()
NSC-17468 ()
Promazine Granules ()
Verophene ()
Combelen ()
Promazina ()
NSC-31447 ()
P&D ID
PD010036
CAS
53-60-1
58-40-2
Tags
available
drug
nuisance
Approved by
FDA
First approval
1956
Drug indication
Psychomotor agitation
Psychosis
Drug Status
vet_approved
approved
withdrawn
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Promazine is a phenothiazine antipsychotic. It is generally prescribed alongside newer antipsychotics such as and .
(GtoPdb)
DESCRIPTION
D2 dopamine receptor antagonist; phenothiazine antipsychotic
(LOPAC library)
DESCRIPTION
Promazine is an antagonist at D2 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors with antipsychotic effects. It belongs to the phenothiazine class of antipsychotics, used to treat schizophrenia.
(Enamine Bioactive Compounds)
DESCRIPTION
Promazine hydrochloride (Romtiazin hydrochloride) is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
3
Compound Sets
29
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
NPC Screening Collection
Nuisance compounds in cellular assays
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
52
Molecular Weight
284.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
4.24
TPSA
6.48
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.83
Structural alerts
1
CAD
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D2
Target
5-HT
Adrenergic Receptor
dopamine
mAChR
ADRA1A, ADRA1B, ADRA1D, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, HRH1, HTR2A, HTR2C
5-HT Receptor,Dopamine Receptor
Indication
schizophrenia
MOA
Dopamine Receptor antagonist
ATC
N05AA03
Pathway
GPCR/G protein
Neuroscience
Therapeutic Class
Antipsychotic Agents
Source data
