General
Preferred name
HYOSCYAMINE
Synonyms
Levsin SL ()
Peptard ()
Levsinex ()
Hyoscyamine Sulphate ()
Levsinex Timecaps ()
Levsin ()
Anaspaz ()
Neoquess ()
Hyoscyamine sulfate hydrate ()
Levsin Sulfate ()
Hyoscyamine (L) ()
L-Hyoscyamine sulfate ()
HYOSCYAMINE HYDROBROMIDE ()
HYOSCYAMINE SULFATE ()
Bellafoline ()
Atropine, (s)- ()
(-)-atropine ()
(-)-hyoscyamine ()
Duboisine ()
(s)-(-)-hyoscyamine ()
Hyoscyaminum ()
Daturine ()
NSC-757064 ()
L-Hyoscyamine ()
Cystospaz ()
L-tropic acid ester with tropine ()
Egazil duretter ()
Egacene ()
Hyoscyamine sulfate dihydrate ()
Hyoscyamine hbr ()
Daturine hbr ()
Daturine hydrobromide ()
Hyoscyaminum hydrobromatum ()
(-)-Hyoscyamine-d3 ()
P&D ID
PD010034
CAS
101-31-5
620-61-1
Tags
available
drug
drug candidate
First approval
1869
Drug Status
approved
Drug indication
Urinary tract infection
Gastrointestinal disease
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
64
DESCRIPTION
L-Hyoscyamine sulfate (Levsin Sulfate) is the sulfate salt of a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits anticholinergic activity. Hyoscyamine functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as well as the eye, heart, bladder, and gastrointestinal tract. These inhibitory effects cause a decrease in saliva, bronchial mucus, gastric juices, and sweat. Furthermore, its inhibitory action on smooth muscle prevents bladder contraction and decreases gastrointestinal motility.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
NPC Screening Collection
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
71
Molecular Weight
289.17
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
1
cLogP
1.93
TPSA
49.77
Fraction CSP3
0.59
Chiral centers
4.0
Largest ring
6.0
QED
0.86
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
mAChR
muscarinic receptor
CHRM1, CHRM2, CHRM3, CHRM4
muscarinic receptors
MOA
AChR antagonist
AChR
acetylcholine receptor antagonist
Indication
peptic ulcer disease (PUD), acute abdominal visceral spasm, ulcerative colitis, interstitial cystitis (IC), enterocolitis, irritable bowel syndrome, tremors, allergic rhinitis
Disease Area
gastroenterology, urology, neurology/psychiatry, allergy
Pathway
Neuroscience
Source data
