General
Preferred name
triprolidine
Synonyms
TRIPROLIDINE HYDROCHLORIDE ()
Pro-Actidil ()
trans-Triprolidine hydrochloride ()
Triprolidine hydrochloride monohydrate ()
Triprolidine (hydrochloride monohydrate) ()
Triprolidine hydrochloride hydrate ()
Triprolidine HCl ()
Myidyl ()
Actidil ()
Actahist ()
Actifed ()
Myfed ()
Corphed ()
Triphed ()
Histafed ()
Allerfed ()
Trilitron ()
NSC-757361 ()
P&D ID
PD010033
CAS
6138-79-0
486-12-4
550-70-9
10191-42-1
Tags
natural product
drug
available
Approved by
FDA
First approval
1983
Drug Status
approved
Drug indication
Hay fever
Antihistaminic
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Marketed formulations often contained triprolidine hydrochloride, but many of these have been discontinued.
(GtoPdb)
DESCRIPTION
Potent H1 histamine receptor antagonist
(LOPAC library)
DESCRIPTION
Standard H1 antagonist, highly potent
(Tocriscreen Total)
DESCRIPTION
Trans-Triprolidine hydrochloride is a potent histamine H1 receptor antagonist with anticholinergic properties. Triprolidine is used for the treatment and prevention of allergy.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Triprolidine hydrochloride hydrate is a potent H1 histamine receptor antagonist. It is used in allergic rhinitis, urticaria and asthma. It is an over-the-counter antihistamine with anticholinergic property. It is used to treat the symptoms associated with allergies and is sometimes combined with other cold medications to relieve flu-like symptoms. It was developed by GlaxoSmithKline and has been listed.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
29
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine BioReference Compounds
Guide to Pharmacology
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
59
Molecular Weight
278.18
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
3.92
TPSA
16.13
Fraction CSP3
0.32
Chiral centers
0.0
Largest ring
6.0
QED
0.84
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
H1
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Neuronal Signaling
Target
H1 receptor
HRH1
Histamine Receptor
MOA
Histamine Receptor antagonist
HRH1 antagonist
Member status
virtual
Indication
allergic rhinitis
Therapeutic Class
Antiallergic Agents
Solubility
alcohol: soluble in 1.5 of solvent, chloroform: soluble in less than 1 of solvent, H2O: soluble 50 mg/mL, clear, colorless to yellow
Source data
