General
Preferred name
triprolidine
Synonyms
TRIPROLIDINE HYDROCHLORIDE ()
Pro-Actidil ()
trans-Triprolidine hydrochloride ()
Triprolidine hydrochloride monohydrate ()
Triprolidine (hydrochloride monohydrate) ()
Triprolidine (hydrochloride) ()
Triprolidine hydrochloride hydrate ()
Histafed ()
Corphed ()
Trilitron ()
Actahist ()
TRIPROLIDINA ()
Myfed ()
Allerfed ()
Triphed ()
Actidil ()
Triprolidine hydrochloride component of actifed ()
NSC-757361 ()
Triprolidine hydrochloride component of corphed ()
Triprolidine hydrochloride component of triphed ()
Triprolidine hydrochloride component of actahist ()
Myidyl ()
Triprolidine hydrochloride component of myfed ()
Triprolidine hydrochloride component of triacin-c ()
Triprolidine hydrochloride component of trilitron ()
Triprolidine hydrochloride component of histafed ()
Triprolidine hydrochloride component of allerfed ()
Triprolidine HCl ()
P&D ID
PD010033
CAS
6138-79-0
486-12-4
550-70-9
10191-42-1
Tags
available
drug
Approved by
FDA
First approval
1982
1983
Drug indication
Seasonal allergic rhinitis
Hay fever
allergic disease
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Marketed formulations often contained triprolidine hydrochloride, but many of these have been discontinued.
(GtoPdb)
DESCRIPTION
Triprolidine hydrochloride monohydrate, a first-generation antihistamine, is an oral active histamine H1 antagonist. Triprolidine hydrochloride monohydrate can be used for the research of allergic rhinitis. Triprolidine hydrochloride monohydrate exhibits spinal motor and sensory block in rats[1][2][3].
PRICE
29
DESCRIPTION
Potent H1 histamine receptor antagonist
(LOPAC library)
DESCRIPTION
Standard H1 antagonist, highly potent
(Tocriscreen Total)
DESCRIPTION
Trans-Triprolidine hydrochloride is a potent histamine H1 receptor antagonist with anticholinergic properties. Triprolidine is used for the treatment and prevention of allergy.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Triprolidine binds to the histamine H1 receptor. It is a first generation antihistamine, used for the symptomatic relief of seasonal or perennial allergic rhinitis or nonallergic rhinitis.
(Enamine Bioactive Compounds)
DESCRIPTION
Triprolidine hydrochloride hydrate is a potent H1 histamine receptor antagonist. It is used in allergic rhinitis, urticaria and asthma. It is an over-the-counter antihistamine with anticholinergic property. It is used to treat the symptoms associated with allergies and is sometimes combined with other cold medications to relieve flu-like symptoms. It was developed by GlaxoSmithKline and has been listed.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Triprolidine hydrochloride monohydrate is a histamine H1 antagonist used in allergic rhinitis, asthma.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
31
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
EUbOPEN Chemogenomics Library
Guide to Pharmacology
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
NCATS Inxight Approved Drugs
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
63
Molecular Weight
278.18
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
3.92
TPSA
16.13
Fraction CSP3
0.32
Chiral centers
0.0
Largest ring
6.0
QED
0.84
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
H1
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Neuronal Signaling
MOA
Histamine Receptor antagonist
HRH1 antagonist
Member status
virtual
Indication
allergic rhinitis
Target
HRH1
Histamine Receptor
H1 receptor
Therapeutic Class
Antiallergic Agents
Solubility
alcohol: soluble in 1.5 of solvent, chloroform: soluble in less than 1 of solvent, H2O: soluble 50 mg/mL, clear, colorless to yellow
Recommended Cell Concentration
100 nM
Source data
