General
Preferred name
NITRIC OXIDE
Synonyms
Inomax ()
Nitric oxide trimer ()
Genosyl ()
Nitrosyl radical ()
Nitrogen oxide (no) ()
Amidogen, oxo- ()
OHM-11771 ()
Inovent ()
P&D ID
PD010028
CAS
10102-43-9
Tags
drug
inorganic
Approved by
EMA
FDA
First approval
1999
Drug indication
Congestive heart failure
Tinea pedis
Respiratory failure
Solid tumour/cancer
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCPRITION A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Compound Sets
9
ChEMBL Approved Drugs
CHEMBL1200689
ChEMBL Drugs
CHEMBL1200689
DrugBank
DB00435
DrugBank Approved Drugs
DB00435
DrugCentral
1948
DrugCentral Approved Drugs
1948
DrugMAP
DM1RBYG
DrugMAP Approved Drugs
DM1RBYG
DrugMatrix
External IDs
37
Properties
(calculated by RDKit )
Molecular Weight
30.0
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.45
TPSA
39.37
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
0.0
QED
0.36
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Therapeutic Class
Bronchodilator Agents
Source data