General
Preferred name
EPIRUBICIN
Synonyms
EPIRUBICIN HYDROCHLORIDE ()
4'-Epidoxorubicin hydrochloride ()
Epirubicin HCl ()
4'-epidoxorubicin HCl ()
Pharmorubicin ()
Ellence ()
4'-Epidoxorubicin ()
Epirubicin (hydrochloride) ()
4'-Epidoxorubicin (hydrochloride) ()
Epirubicin (IMI 28) HCl ()
Ellence, Pharmorubicin, Epirubicin Ebewe,IMI 28, NSC?256942, 4'-epidoxorubicin,Epirubicin hydrochloride ()
IMI-28 ()
Farmorubicin ()
NSC-759195 ()
WP-697 ()
Farmorubicina ()
4'-epi-adriamycin ()
Epiadriamycin ()
NSC-256942 ()
Epidoxorubicin ()
P&D ID
PD010023
CAS
56420-45-2
56390-09-1
Tags
natural product
drug
available
Approved by
FDA
First approval
1999
Drug Status
approved
Drug indication
Antineoplastic
Solid tumour/cancer
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
20
Organisms
0
Compound Sets
20
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
LINCS compound set
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
57
Properties
(calculated by RDKit )
Molecular Weight
543.17
Hydrogen Bond Acceptors
12
Hydrogen Bond Donors
6
Rotatable Bonds
5
Ring Count
5
Aromatic Ring Count
2
cLogP
0.0
TPSA
206.07
Fraction CSP3
0.44
Chiral centers
6.0
Largest ring
6.0
QED
0.24
Structural alerts
6
quinone_A(370)
[!#6&!#1]=[#6]-1-[#6]=,:[#6]-[#6](=[!#6&!#1])-[#6]=,:[#6]-1
PAINS Family A
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Intercalation
Nuisance compounds in cellular assays
Optical interference
Fluorescence
Nuisance compounds in cellular assays
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Target
Topoisomerase
Topo
Apoptosis
CHD1, TOP2A
antibiotic
DNA/RNA Synthesis
Apoptosis related,Topoisomerase
Pathway
Cell Cycle/DNA Damage
DNA Damage/DNA Repair
Anti-infection
Indication
breast cancer
MOA
Topoisomerase inhibitor
Therapeutic Class
Anticancer Agents
Source data
