General
Preferred name
CHLORAMPHENICOL
Synonyms
Chloromycetin ()
Chlorofair ()
9-phenyl-9h-xanthen-9-ol ()
Chloroptic S.O.P. ()
Chloramphenicol component of chloromycetin hydrocortisone ()
Mychel ()
Chloramex ()
Sno Phenicol ()
NSC-3069 ()
9-hydroxy-9-phenylxanthene ()
Ophthochlor ()
Tubilux Infected Eyes ()
Golden Eye Antibiotic ()
Xanthen-9-ol, 9-phenyl- ()
Cloranfenicol ()
Brolene Antibiotic ()
Klorafect ()
Chloramphenicol component of chloromyxin ()
Kemicetine ()
Kernispray ()
Chloramphenicol component of elase-chloromycetin ()
Optomycin ()
Econochlor ()
Amphicol ()
Brochlor ()
Tevcocin ()
NSC-16331 ()
Chloramphenicol component of chloroptic-p s.o.p. ()
Chloroptic ()
Chloramphenicol component of ophthocort ()
Chloramphenicol ()
P&D ID
PD010022
CAS
2787-09-9
137731-90-9
56-75-7
Tags
available
drug
Approved by
FDA
First approval
1950
Drug indication
osteomyelitis
Bacterial infection
Drug Status
vet_approved
approved
withdrawn
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Chloramphenicol is a semisynthetic, broad-spectrum antibacterial derived from Streptomyces venequelae. Its activity is primarily bacteriostatic. (GtoPdb)
DESCRIPTION Chloramphenicol, a broad-spectrum antibiotic, acts as a potent inhibitor of bacterial protein biosynthesis. Chloramphenicol acts primarily on the 50S subunit of bacterial 70S rihosomes and inhibits peptide bond formation by suppressing peptidyl transferase activity. It is used in treatment of cholera, as it destroys the vibrios and decreases the diarrhea. (Enamine Bioactive Compounds)
Cell lines
0
Organisms
15
Compound Sets
19
AdooQ Bioactive Compound Library
A10200
ChEMBL Approved Drugs
CHEMBL130
ChEMBL Drugs
CHEMBL130
Concise Guide to Pharmacology 2023/24
10901
Drug Repurposing Hub
DrugBank
DB00446
DrugBank Approved Drugs
DB00446
DrugCentral
589
DrugCentral Approved Drugs
589
DrugMAP
DMFXEWT
DrugMAP Approved Drugs
DMFXEWT
Enamine Bioactive Compounds
EBC-07470
Enamine BioReference Compounds
Guide to Pharmacology
10901
MedChem Express Bioactive Compound Library
HY-B0239
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Chloramphenicol(Chloromycetin)
External IDs
52
Properties
(calculated by RDKit )
Molecular Weight
322.01
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
1
Aromatic Ring Count
1
cLogP
0.91
TPSA
112.7
Fraction CSP3
0.36
Chiral centers
2.0
Largest ring
6.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
meningitis, fever, cholera
Disease Area
infectious disease, endocrinology
Target
CD55
Akt
antibiotic
Apoptosis
Autophagy
Bacterial
Beclin1
HIF/HIF Prolyl-Hydroxylase
JNK
MMP
VEGFR
Antibiotics for Plant Cell Culture,Bacterial,Selection Antibiotics for Transfected Cell
MOA
bacterial 50S ribosomal subunit inhibitor
Therapeutic Class
Antibiotics
Pathway
Anti-infection
MAPK/ERK Pathway
Metabolic Enzyme/Protease
PI3K/Akt/mTOR
Protein Tyrosine Kinase/RTK
Source data