General
Preferred name
cefalotin
Synonyms
CEPHALOTHIN SODIUM ()
cephalothin ()
Cephalothin sodium salt ()
Cefalotin sodium ()
Cephalotin acid ()
Cephalothin (sodium) ()
Cephalotin ()
Cefalotin sodium, Sodium cephalotin ()
Cephalothin, Cefalotin, Cephalothinum ()
Toricelocin ()
Synclotin ()
Keflin ()
Seffin ()
Sodium cephalothin ()
NSC-756667 ()
38253 ()
Averon ()
Cefalotin ()
Cefalotine ()
Cefalotina ()
Cephalothin ()
Cefalothin ()
Cefalothin (sodium salt) ()
P&D ID
PD010018
CAS
58-71-9
153-61-7
11048-05-8
Tags
available
covalent binder
drug
Approved by
FDA
First approval
1974
Drug indication
bacterial disease
Bacterial infection
Drug Status
vet_approved
approved
investigational
withdrawn
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Cephalothin sodium is a first-generation cephalosporin antibiotic with broad antibacterial activity and is effective against Gram-positive and Gram-negative bacteria.
DESCRIPTION
Cefalotin is a semisynthetic, first generation cephalosporin belonging to the β-lactam class of antibacterial compounds .
(GtoPdb)
PRICE
29
DESCRIPTION
Cephalothin (Cephalotin) is a semi-synthetic cephalosporin antibiotic and beta-lactam antibiotic. Cephalothin inhibits class C ¦Â-lactamase AmpC, with an Ki of 0.32 ¦ÌM. Cephalothin binds to penicillin-binding proteins, interfering with the cross-linking of peptidoglycan in the cell wall and thus hindering the normal synthesis of the bacterial cell wall. Cephalothin shows antibacterial activity against a variety of bacteria. Cephalothin can be used in hematological and nephrotoxicity studies[1][2][3][4][5][6][7].
DESCRIPTION
Cephalothin is a beta-lactam antibiotic, inhibits class C ??-lactamase AmpC (Ki: 0.32 ??M).
DESCRIPTION
Semi-synthetic cephalosporin antibiotic; interferes with cell wall synthesis
(LOPAC library)
DESCRIPTION
Cephalothin sodium (Cefalotin) binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Cephalothin sodium (Cefalotin) is the sodium salt form of cephalothin, a semisynthetic, beta-lactam, the first-generation cephalosporin antibiotic with bactericidal activity. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Cefalotin is a cephalosporin antibiotic. It is used to prevent infection during surgery and to treat many kinds of infections of the blood, bone or joints, respiratory tract, skin, and urinary tract. The bactericidal activity of cefalotin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins.
(Enamine Bioactive Compounds)
DESCRIPTION
Cephalothin is a beta-lactam antibiotic, inhibits class C β-lactamase AmpC (Ki: 0.32 μM).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
28
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
76
Molecular Weight
396.04
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
1
cLogP
0.59
TPSA
113.01
Fraction CSP3
0.38
Chiral centers
2.0
Largest ring
6.0
QED
0.53
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Cell wall synthesis
Target
antibiotic
Bacterial
PBPs
β-Lactamase
Beta-lactamase
Antibiotics,Antibiotics for Mammalian Cell Culture,Bacterial
Indication
skin infections, surgical prophylaxis
MOA
bacterial cell wall synthesis inhibitor
ATC
J01DB03
Pathway
Microbiology/virology
Anti-infection
Therapeutic Class
Antibiotics
Antiinfective Agents
Source data
