General
Preferred name
quinine
Synonyms
Quinine bimuriate ()
Quinine (hydrochloride dihydrate) ()
Quinine HCl Dihydrate ()
Quinine sulfate dihydrate ()
QUININE DIHYDROCHLORIDE ()
Quinine sulfate ()
QUININE HYDROCHLORIDE ()
QUININE BISULFATE ()
QUININE SALICYLATE ()
QUININE HYDROBROMIDE ()
QUININE GLYCEROPHOSPHATE ()
QUININE PHOSPHATE ()
QUININE ASCORBATE ()
Rezquin ()
WR297608 ()
NSC-192949 ()
(8s,9r)-6'-methoxycinchonan-9-ol ()
Chininum purum ()
Quinine sulfate hydrate ()
NSC-5362 ()
Quinamm ()
NSC-757298 ()
Anhydrous quinine sulfate ()
GLS1200 ()
Gls-1200 ()
Quinine hemisulfate anhydrous ()
Quinine, sulfate (2:1) (salt) ()
Chininum sulphuricum ()
FEMA NO. 2977 ()
Quinine sulfate anhydrous ()
Quinine sulphate ()
Qualaquin ()
Quinine sulfate (2:1) ()
Gls 1200 ()
Quinate ()
Quinini dihydrochloridum ()
Neutral quinine hydrochloride ()
Acid quinine hydrochloride ()
Anhydrous quinine hydrochloride ()
Chininum muriaticum ()
Quinine hydrochloride dihydrate ()
Quinine hydrochloride hydrate ()
FEMA NO. 2976 ()
FEMA NO. 2976, DIHYDRATE- ()
Quinine muriate ()
Quinine monohydrochloride ()
Quinine hydrochloride anhydrous ()
Quinini hydrochloridum ()
Quinine hcl ()
Quinine bisulfate heptahydrate ()
Quinine bisulfate anhydrous ()
Biquinate ()
Anhydrous quinine bisulfate ()
Quinine, sulfate (1:1) (salt) ()
Quinini bisulfas ()
Quinine bisulphate heptahydrate ()
Quinine hydrogen sulfate ()
FEMA NO. 2975 ()
Quinine, monohydrobromide ()
Quinine hbr ()
Quinine hydrobromide monohydrate ()
Anhydrous quinine hydrobromide ()
Quinine hydrobromide anhydrous ()
Quinine, monohbr ()
Chininum salicylicum ()
Quinine, monosalicylate ()
Kineurine ()
Quinine biascorbate ()
Quinine phosphate, anhydrous ()
Quinine, phosphate (3:2) (salt) ()
P&D ID
PD010011
CAS
1407-83-6
72402-53-0
130-95-0
750-90-3
6119-47-7
6119-70-6
60-93-5
Tags
available
drug
natural product
drug candidate
Approved by
FDA
First approval
2005
Drug indication
Kidney disease
Malaria
Drug Status
approved
investigational
Max Phase
1.0
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 ¦ÌM[1][2].
DESCRIPTION Extracted from the bark of the cinchona tree, quinine has also been synthesised in the laboratory
DESCRIPTION Extracted from the bark of the cinchona tree, quinine has also been synthesised in the laboratory.
Quinine is one of the key antimalarial drugs listed in the WHO 20th Essential Medicines List (2017).
DESCRIPTION Extracted from the bark of the cinchona tree, quinine has also been synthesized in the laboratory .
DESCRIPTION First extracted from the bark of the cinchona tree and used as an antimalarial medicine, quinine has also been synthesized in the laboratory .

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
PRICE 29
PRICE 29
PRICE 29
DESCRIPTION Quinine is an antimalarial agent. It inhibits cholinesterase, multidrug resistance protein 1, cytochrome P450. It is used to treat uncomplicated Plasmodium falciparum malaria. (Enamine Bioactive Compounds)
DESCRIPTION Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cramps. Quinine therapy has been associated with rare instances of hypersensitivity reactions which can be accompanied by hepatitis and mild jaundice. (TargetMol Bioactive Compound Library)
DESCRIPTION Quinine sulfate dihydrate plays a major role in potassium channel blockers. It is also used as an antimalarial, anticholinergic, antihypertensive and a hypoglycemic agent. It inhibits mitochondrial ATP-regulated potassium channel. It is also used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes. (TargetMol Bioactive Compound Library)
DESCRIPTION Quinine dihydrochloride (Quinine bimuriate) is a primary alkaloid of various species of Cinchona (Rubiaceae). It is also an antimalarial and muscle relaxant (skeletal). (TargetMol Bioactive Compound Library)
Cell lines
4
Organisms
3
Compound Sets
26
Cayman Chemical Bioactives
23958
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL170
CHEMBL2359966
ChEMBL Drugs
CHEMBL170
CHEMBL2359966
CHEMBL2146088
CHEMBL2146083
CHEMBL588046
CHEMBL2146105
CHEMBL2146084
CHEMBL3707252
CHEMBL3707329
CHEMBL3707332
Concise Guide to Pharmacology 2017/18
2510
Concise Guide to Pharmacology 2019/20
2510
Concise Guide to Pharmacology 2021/22
2510
Concise Guide to Pharmacology 2023/24
2510
Drug Repurposing Hub
DrugBank
DB00468
DrugBank Approved Drugs
DB00468
DrugCentral
4523
DrugCentral Approved Drugs
4523
DrugMAP
DMSWYF5
DrugMAP Approved Drugs
DMSWYF5
Enamine Bioactive Compounds
EBC-03912
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101583
Guide to Pharmacology
2510
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL170
MedChem Express Bioactive Compound Library
HY-B0433A
NCATS Inxight Approved Drugs
A7V27PHC7A
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
Quinine-hydrochloride-dihydrate
quinine
TargetMol Bioactive Compound Library
T0690
TN4883
T4333
External IDs
147
Properties
(calculated by RDKit )
Molecular Weight
324.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
2
cLogP
3.17
TPSA
45.59
Fraction CSP3
0.45
Chiral centers
5.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Unknown molecular target
hemozoin biocrystallization inhibitor
Target
Ferriprotoporphyrin IX
Parasite
Platelet glycoprotein IX
Potassium Channel
GP9, KCNB2, KCNN4, SLC29A4
Dengue virus
Flavivirus
Indication
malaria
Pathway
Membrane Transporter/Ion Channel
Microbiology/virology
Anti-infection
Therapeutic Class
Antimalarials
Source data