General
Preferred name
quinine
Synonyms
Quinine bimuriate ()
QUININE DIHYDROCHLORIDE ()
Quinine (hydrochloride dihydrate) ()
QUININE HYDROBROMIDE ()
QUININE HYDROCHLORIDE ()
QUININE BISULFATE ()
QUININE SALICYLATE ()
Quinine sulfate ()
QUININE GLYCEROPHOSPHATE ()
QUININE PHOSPHATE ()
QUININE ASCORBATE ()
Quinine HCl Dihydrate ()
Rezquin ()
NSC-192949 ()
(8s,9r)-6'-methoxycinchonan-9-ol ()
WR297608 ()
Chininum purum ()
NSC-757298 ()
Quinine sulfate hydrate ()
GLS1200 ()
Quinine sulphate ()
Quinine sulfate anhydrous ()
Quinine sulfate (2:1) ()
FEMA NO. 2977 ()
Chininum sulphuricum ()
Quinine sulfate dihydrate ()
Quinamm ()
Quinine hemisulfate anhydrous ()
Quinate ()
Gls 1200 ()
NSC-5362 ()
Quinine, sulfate (2:1) (salt) ()
Anhydrous quinine sulfate ()
Gls-1200 ()
Qualaquin ()
Quinini hydrochloridum ()
Quinine hydrochloride anhydrous ()
FEMA NO. 2976, DIHYDRATE- ()
Quinine hcl ()
Quinine hydrochloride dihydrate ()
Quinine hydrochloride hydrate ()
FEMA NO. 2976 ()
Chininum muriaticum ()
Quinine muriate ()
Anhydrous quinine hydrochloride ()
Quinine monohydrochloride ()
Quinine, sulfate (1:1) (salt) ()
Quinine bisulphate heptahydrate ()
Quinini bisulfas ()
Quinine hydrogen sulfate ()
Quinine bisulfate anhydrous ()
Anhydrous quinine bisulfate ()
Quinine bisulfate heptahydrate ()
FEMA NO. 2975 ()
Biquinate ()
Acid quinine hydrochloride ()
Neutral quinine hydrochloride ()
Quinini dihydrochloridum ()
Quinine, monohbr ()
Anhydrous quinine hydrobromide ()
Quinine, monohydrobromide ()
Quinine hbr ()
Quinine hydrobromide monohydrate ()
Quinine hydrobromide anhydrous ()
Chininum salicylicum ()
Quinine, monosalicylate ()
Kineurine ()
Quinine, phosphate (3:2) (salt) ()
Quinine phosphate, anhydrous ()
Quinine biascorbate ()
P&D ID
PD010011
CAS
130-95-0
60-93-5
1407-83-6
72402-53-0
750-90-3
6119-47-7
Tags
drug candidate
natural product
drug
available
Approved by
FDA
First approval
2005
Drug Status
approved
Drug indication
Deterrent (smoking)
Antimalarial
Antimalarial,Deterrent (smoking)
Malaria
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Extracted from the bark of the cinchona tree, quinine has also been synthesised in the laboratory
DESCRIPTION Extracted from the bark of the cinchona tree, quinine has also been synthesised in the laboratory.
Quinine is one of the key antimalarial drugs listed in the WHO 20th Essential Medicines List (2017).
DESCRIPTION Extracted from the bark of the cinchona tree, quinine has also been synthesized in the laboratory .
DESCRIPTION First extracted from the bark of the cinchona tree and used as an antimalarial medicine, quinine has also been synthesized in the laboratory .

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
Cell lines
4
Organisms
5
Compound Sets
25
Cayman Chemical Bioactives
23958
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL170
CHEMBL2359966
CHEMBL2146088
CHEMBL2146083
CHEMBL588046
ChEMBL Drugs
CHEMBL170
CHEMBL2359966
CHEMBL2146088
CHEMBL2146083
CHEMBL588046
CHEMBL2146105
CHEMBL2146084
CHEMBL3707252
CHEMBL3707329
CHEMBL3707332
Concise Guide to Pharmacology 2017/18
2510
Concise Guide to Pharmacology 2019/20
2510
Concise Guide to Pharmacology 2021/22
2510
Concise Guide to Pharmacology 2023/24
2510
Drug Repurposing Hub
DrugBank
DB00468
DrugBank Approved Drugs
DB00468
DrugCentral
4523
DrugCentral Approved Drugs
4523
DrugMAP
DMSWYF5
DrugMAP Approved Drugs
DMSWYF5
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101583
Guide to Pharmacology
2510
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL170
MedChem Express Bioactive Compound Library
HY-B0433A
NCATS Inxight Approved Drugs
A7V27PHC7A
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
Quinine-hydrochloride-dihydrate
quinine
TargetMol Bioactive Compound Library
T0690
T4333
External IDs
139
Properties
(calculated by RDKit )
Molecular Weight
324.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
2
cLogP
3.17
TPSA
45.59
Fraction CSP3
0.45
Chiral centers
5.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Unknown molecular target
hemozoin biocrystallization inhibitor
Target
Ferriprotoporphyrin IX
Fe(II)-protoporphyrin IX
Platelet glycoprotein IX
Potassium Channel
GP9, KCNB2, KCNN4, SLC29A4
Dengue virus
Flavivirus
Parasite
Pathway
Membrane Transporter/Ion Channel
Anti-infection
Indication
malaria
Therapeutic Class
Antimalarials
Source data