General
Preferred name
FLUOXETINE
Synonyms
FLUOXETINE HYDROCHLORIDE ()
LY-110140 (free base) ()
Fluoxetine HCl ()
LY-110140 ()
Lilly110140 ()
Fluoxetine (HCl) ()
Prozac, Sarafem,LY-110140 ()
Fluoxetine (Lilly 110140) HCl ()
Fluoxetine (hydrochloride) ()
Fluoxetine-d5 (hydrochloride) ()
Fluoxetine hydrochloride component of symbyax ()
SARAFEM ()
FLUCTIN ()
FLUSOL ()
OXACTIN ()
PROZAC WEEKLY ()
OLENA ()
FLUOXEREN ()
PROZAC ()
FLUOX-PUREN ()
PROZAC 60 ()
PROZIT ()
FONTEX ()
SELFEMRA ()
ADOFEN ()
RANFLUTIN ()
LOVAN ()
FELICIUM ()
LY110140 ()
PROZEP ()
FLUNEURIN ()
FLUXET ()
FLUOXETINE (AS HYDROCHLORIDE) ()
FOXETIN ()
RECONCILE ()
NSC-283480 ()
Symbyax ()
NSC-758685 ()
Fluval ()
Fluoxetina ()
Fluoxetin ratiopharm ()
Fluoxetine ()
Prozac(R) ()
Fluoxetine (hydrochloride) (CRM) ()
FLUOXETINE HYDROCHLORIDE COMPONENT OF SYMBYAX ()
P&D ID
PD010007
CAS
56296-78-7
52341-67-0
59333-67-4
100568-02-3
54910-89-3
1173020-43-3
Tags
available
drug
nuisance
Approved by
FDA
First approval
1987
Drug indication
Stroke
panic disorder
Depression
Drug Status
vet_approved
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
HALF-LIFE 1-3 days [acute administration];; 4-6 days [chronic administration];; 4-16 days [norfluoxetine, acute and chronic administration].
DESCRIPTION The approved drug fluoxetine is a racemic mixture of two enantiomers; (R)-fluoxetine and (S)-Fluoxetine. The structure shown here does not specify stereochemistry and represents the mixture. The two PDB links listed above represent the two enantiomers. Fluoxetine is metabolised in the body to active metabolite . (GtoPdb)
PRICE 29
DESCRIPTION sigma1 selective antagonist (Tocris Bioactive Compound Library)
DESCRIPTION 5-HT re-uptake inhibitor (Tocriscreen Plus)
DESCRIPTION Selective serotonin reuptake inhibitor (LOPAC library)
DESCRIPTION 5-HT re-uptake inhibitor (Tocriscreen Total)
DESCRIPTION Fluoxetine HCl is a selective serotonin reuptake inhibitor. Fluoxetine HCl have been used in the treatment of major depression as well as other psychiatric disorders. (Enamine Bioactive Compounds)
DESCRIPTION Fluoxetine hydrochloride (Lilly110140) is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants. (TargetMol Bioactive Compound Library)
DESCRIPTION Fluoxetine (LY-110140) is a highly specific serotonin uptake inhibitor and selective 5-hydroxytryptamine (5-HT) reuptake inhibitor. Fluoxetine has antidepressant activity. (TargetMol Bioactive Compound Library)
Cell lines
4
Organisms
8
Compound Sets
39
Axon Medchem Screening Library
1302
Cayman Chemical Bioactives
14418
32720
18253
ChEMBL Approved Drugs
CHEMBL1201082
CHEMBL41
ChEMBL Drugs
CHEMBL1201082
CHEMBL41
Concise Guide to Pharmacology 2017/18
203
Concise Guide to Pharmacology 2019/20
203
Concise Guide to Pharmacology 2021/22
203
Concise Guide to Pharmacology 2023/24
203
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00472
DrugBank Approved Drugs
DB00472
DrugCentral
1209
DrugCentral Approved Drugs
1209
DrugMAP
DM3PD2C
DrugMAP Approved Drugs
DM3PD2C
DrugMatrix
Enamine Bioactive Compounds
EBC-03850
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101181
EUbOPEN Chemogenomics Library
EUB0000428
Guide to Pharmacology
203
Ki Database
FLUOXETINE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1201082
CHEMBL41
NCATS Inxight Approved Drugs
01K63SUP8D
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Nuisance compounds in cellular assays
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Fluoxetine-hydrochloride
TargetMol Bioactive Compound Library
T0450L
T0450
The Pathogen Box
The Spectrum Collection
Tocris Bioactive Compound Library
0927
Tocriscreen Plus
0927
Tocriscreen Total
External IDs
82
Properties
(calculated by RDKit )
Molecular Weight
309.13
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
4.44
TPSA
21.26
Fraction CSP3
0.29
Chiral centers
1.0
Largest ring
6.0
QED
0.85
Structural alerts
1
CAD
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target Type
Transporters
Selectivity
Reuptake
Disease
KINETOPLASTIDS
Pathway
Neuronal Signaling
Autophagy
GPCR/G protein
Neuroscience
Immunology/Inflammation
Primary Target
5-HT Transporters
MOA
Inhibitor
Sodium Channel Blockers
Serotonin Transporter (SERT) Inhibitors
selective serotonin reuptake inhibitor (SSRI)
Member status
member
Indication
depression, obsessive compulsive disorder (OCD), bulimia nervosa, panic disorders, bipolar disorder
Target
ANO1, HTR2B, SLC6A4
SSRI
5-HT Receptor
5-HT
Serotonin Transporter
Sert (Sodium-dependent)
MRP1
Therapeutic Class
Antidepressants
Recommended Cell Concentration
1 uM
Source data