General
Preferred name
RIMANTADINE
Synonyms
RIMANTADINE HYDROCHLORIDE ()
Flumadine ()
Rimantadine HCL ()
Meradane ()
Rimantadine isomer 1 ()
Rimantadine (hydrochloride) ()
1-Rimantadine ()
Roflual ()
NSC-206764 ()
EXP-126 ()
Meradan ()
EXP 126 ()
Rimantadin ()
P&D ID
PD010003
CAS
13392-28-4
1501-84-4
Tags
natural product
drug
available
Approved by
FDA
First approval
1993
Drug Status
investigational
approved
Drug indication
Influenza A virus infection
Discovery agent
Antiviral
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
The mechanism of action of rimantadine is not fully understood. Rimantadine appears to exert its inhibitory effect early in the viral replicative cycle, possibly inhibiting the uncoating of the virus. The protein coded by the M2 gene of influenza A may play an important role in rimantadine susceptibility.
DESCRIPTION
Rimantadine, an adamantane derivative, could be an effective antiviral drug and probably prevent influenza virus at some extent.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Rimantadine hydrochloride, also called as Flumadine, is a nucleic acid synthesis inhibitor and an anti-influenza virus drug.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
5
Compound Sets
24
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
LSP-MoA library (Laboratory of Systems Pharmacology)
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Pandemic Response Box
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
55
Molecular Weight
179.17
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
0
cLogP
2.55
TPSA
26.02
Fraction CSP3
1.0
Chiral centers
1.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
Anti-infection
Target
RNA Synthesis
Influenza Virus
DNA/RNA Synthesis
Therapeutic Class
Antiviral Agents
Solubility
Soluble to ≥ 2.5 mg/mL in DMSO
DMSO 33 mg/mL
Water 33 mg/mL
Source data
