General
Preferred name
PEFLOXACIN
Synonyms
PEFLOXACINE MESYLATE ()
PEFLOXACIN MESYLATE ()
41 982 RP ()
Pefloxacin (mesylate dihydrate) ()
Pefloxacinium mesylate dihydrate ()
Pefloxacinium ()
Pefloxacinium mesylate ()
1589 RB ()
Pefloxacine ()
Pefloxacin (mesylate) ()
Pefloxacin Mesylate Dihydrate ()
1589 RB,Pefloxacinium mesylate dihydrate ()
41-982-RP ()
NSC-758944 ()
Pefloxacin mesilate ()
Pefloxacin methanesulfonate ()
EU-5306 ()
1589-RB ()
Pefloxacin (mesylate hydrate) ()
P&D ID
PD009999
CAS
70458-95-6
70458-92-3
149676-40-4
Tags
drug candidate
natural product
drug
available
First approval
1985
Drug Status
approved
Drug indication
Antibacterial
Gonococcal urethritis
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Pefloxacin is a fluoroquinolone compound with broad-spectrum antibacterial activity.
(GtoPdb)
DESCRIPTION
Pefloxacin Mesylate is a synthetic chemotherapeutic agent and an antibacterial agent with IC50 of 6.7 nM.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
3
Compound Sets
21
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
61
Molecular Weight
333.15
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
1.61
TPSA
65.78
Fraction CSP3
0.41
Chiral centers
0.0
Largest ring
6.0
QED
0.92
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Bacterial
Topo IV
TOP2A
antibiotic
Topoisomerase
Pathway
Anti-infection
DNA Damage/DNA Repair
MOA
Topoisomerase inhibitor
bacterial DNA gyrase inhibitor
Indication
gastrointestinal infections, urethritis, gonorrhea, urinary tract infections
Disease Area
infectious disease, urology
Therapeutic Class
Antiinfective Agents
Source data
